riluzole has been researched along with Endolymphatic Hydrops in 2 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Endolymphatic Hydrops: An accumulation of ENDOLYMPH in the inner ear (LABYRINTH) leading to buildup of pressure and distortion of intralabyrinthine structures, such as COCHLEA and SEMICIRCULAR CANALS. It is characterized by SENSORINEURAL HEARING LOSS; TINNITUS; and sometimes VERTIGO.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study tests whether riluzole, a glutamate release inhibitor, and dimethylsulfoxide (DMSO), an anti-inflammatory and antioxidant solvent with favorable properties at the level of glutamate receptors, can protect against early-stage hearing loss in a mouse model of ELH." | 3.76 | Pharmacological protection of hearing loss in the mouse model of endolymphatic hydrops. ( Alagramam, KN; Frankel, JK; Heddon, CM; Levitt, AH; Megerian, CA; Melki, SJ; Momin, SR, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Melki, SJ | 2 |
| Heddon, CM | 1 |
| Frankel, JK | 1 |
| Levitt, AH | 1 |
| Momin, SR | 2 |
| Alagramam, KN | 1 |
| Megerian, CA | 2 |
| Obokhare, JO | 1 |
| Fares, SA | 1 |
| Semaan, MT | 1 |
2 other studies available for riluzole and Endolymphatic Hydrops
| Article | Year |
|---|---|
Pharmacological protection of hearing loss in the mouse model of endolymphatic hydrops.
Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; Endolymphatic Hydrops; Hearing Loss; Mice; Neur | 2010 |
Hearing preservation in Guinea pigs with long-standing endolymphatic hydrops.
Topics: Animals; Cochlea; Dimethyl Sulfoxide; Endolymphatic Hydrops; Evoked Potentials, Auditory, Brain Stem | 2011 |