riluzole has been researched along with Depressive Disorder, Treatment-Resistant in 5 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Depressive Disorder, Treatment-Resistant: Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies. (Campbell's Psychiatric Dictionary, 9th ed.)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Riluzole is a glutamate-modulating agent with neuroprotective properties approved for use in amyotrophic lateral sclerosis." | 2.84 | A Randomized, Double-Blind, Placebo-Controlled, Sequential Parallel Comparison Design Trial of Adjunctive Riluzole for Treatment-Resistant Major Depressive Disorder. ( Brandt, C; Fava, M; Gueorguieva, R; Mathew, SJ; Sanacora, G, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sakurai, H | 1 |
| Dording, C | 1 |
| Yeung, A | 1 |
| Foster, S | 1 |
| Jain, F | 1 |
| Chang, T | 1 |
| Trinh, NH | 1 |
| Bernard, R | 1 |
| Boyden, S | 1 |
| Iqbal, SZ | 1 |
| Wilkinson, ST | 2 |
| Mathew, SJ | 3 |
| Mischoulon, D | 1 |
| Fava, M | 2 |
| Cusin, C | 1 |
| Gueorguieva, R | 1 |
| Brandt, C | 1 |
| Sanacora, G | 1 |
| Kiselycznyk, C | 1 |
| Banasr, M | 1 |
| Webler, RD | 1 |
| Haile, C | 1 |
| Niciu, MJ | 2 |
| Luckenbaugh, DA | 2 |
| Ionescu, DF | 2 |
| Richards, EM | 2 |
| Vande Voort, JL | 2 |
| Ballard, ED | 2 |
| Brutsche, NE | 2 |
| Furey, ML | 2 |
| Zarate, CA | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
5 trials available for riluzole and Depressive Disorder, Treatment-Resistant
| Article | Year |
|---|---|
Longer-term open-label study of adjunctive riluzole in treatment-resistant depression.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Treatment-Resistant; Drug Administration Schedule | 2019 |
A Randomized, Double-Blind, Placebo-Controlled, Sequential Parallel Comparison Design Trial of Adjunctive Riluzole for Treatment-Resistant Major Depressive Disorder.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Trea | 2017 |
Serum and plasma brain-derived neurotrophic factor and response in a randomized controlled trial of riluzole for treatment resistant depression.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disord | 2018 |
Riluzole likely lacks antidepressant efficacy in ketamine non-responders.
Topics: Adult; Depressive Disorder, Treatment-Resistant; Dose-Response Relationship, Drug; Excitatory Amino | 2014 |
Ketamine's antidepressant efficacy is extended for at least four weeks in subjects with a family history of an alcohol use disorder.
Topics: Adolescent; Adult; Aged; Alcohol-Related Disorders; Antidepressive Agents; Depressive Disorder, Majo | 2014 |