riluzole has been researched along with Depression, Endogenous in 5 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glutamatergic modulators may have therapeutic potential in the treatment of depressive disorder (DD), riluzole, as a modulating drug of the glutamatergic system, its antidepressant efficacy and safety of riluzole for DD are inconsistent." | 9.05 | Efficacy and safety of riluzole for depressive disorder: A systematic review and meta-analysis of randomized placebo-controlled trials. ( Wang, G; Wang, H; Wu, C; Yao, R; Yuan, M, 2020) |
| "Glutamatergic modulators may have therapeutic potential in the treatment of depressive disorder (DD), riluzole, as a modulating drug of the glutamatergic system, its antidepressant efficacy and safety of riluzole for DD are inconsistent." | 5.05 | Efficacy and safety of riluzole for depressive disorder: A systematic review and meta-analysis of randomized placebo-controlled trials. ( Wang, G; Wang, H; Wu, C; Yao, R; Yuan, M, 2020) |
| " We evaluated the evidence from randomized controlled trials (RCTs) regarding the use of the glutamatergic drug riluzole in mental illnesses; and conducted preliminary meta-analyses of its effectiveness in treating obsessive-compulsive disorder (OCD) and depression." | 5.01 | Efficacy and tolerability of riluzole in psychiatric disorders: A systematic review and preliminary meta-analysis. ( Amelsvoort, TV; de Boer, JN; Hirdes, M; McAlonan, GM; Vingerhoets, C; Zinkstok, JR, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yao, R | 1 |
| Wang, H | 1 |
| Yuan, M | 1 |
| Wang, G | 1 |
| Wu, C | 1 |
| de Boer, JN | 1 |
| Vingerhoets, C | 1 |
| Hirdes, M | 1 |
| McAlonan, GM | 1 |
| Amelsvoort, TV | 1 |
| Zinkstok, JR | 1 |
| Stukovnik, V | 1 |
| Zidar, J | 1 |
| Podnar, S | 1 |
| Repovs, G | 1 |
| Takahashi, K | 1 |
| Murasawa, H | 1 |
| Yamaguchi, K | 1 |
| Yamada, M | 2 |
| Nakatani, A | 1 |
| Yoshida, M | 1 |
| Iwai, T | 1 |
| Inagaki, M | 1 |
| Saitoh, A | 1 |
| Paslakis, G | 1 |
| Gass, P | 1 |
| Deuschle, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dextromethorphan as an Augmentation Agent in Treatment-resistant Schizophrenia: A Randomized, Group Sequential Adaptive Design, Controlled Clinical Trial[NCT05944510] | Phase 4 | 72 participants (Anticipated) | Interventional | 2023-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for riluzole and Depression, Endogenous
| Article | Year |
|---|---|
Efficacy and safety of riluzole for depressive disorder: A systematic review and meta-analysis of randomized placebo-controlled trials.
Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder; Female; Humans; Ketamine; Male; Middl | 2020 |
Efficacy and tolerability of riluzole in psychiatric disorders: A systematic review and preliminary meta-analysis.
Topics: Adult; Autistic Disorder; Depressive Disorder; Female; Humans; Male; Mental Disorders; Neuroprotecti | 2019 |
[The role of the glutamatergic system in pathophysiology and pharmacotherapy for depression: preclinical and clinical data].
Topics: Animals; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Excitatory Amino Acid | 2011 |
2 other studies available for riluzole and Depression, Endogenous
| Article | Year |
|---|---|
Amyotrophic lateral sclerosis patients show executive impairments on standard neuropsychological measures and an ecologically valid motor-free test of executive functions.
Topics: Algorithms; Amyotrophic Lateral Sclerosis; Back; Cognition Disorders; Depressive Disorder; Diagnosti | 2010 |
Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Depressive Di | 2011 |