riluzole has been researched along with Chronic Progressive Multiple Sclerosis in 7 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a run-in versus treatment trial, we show that the neuroprotective agent riluzole seems to reduce the rate of cervical cord atrophy and the development of hypointense T1 brain lesions on magnetic resonance imaging." | 5.10 | The effect of the neuroprotective agent riluzole on MRI parameters in primary progressive multiple sclerosis: a pilot study. ( Barkhof, F; Bergers, E; Kalkers, NF; Polman, CH; van Schijndel, R, 2002) |
| "It is hoped that therapeutics in primary progressive multiple sclerosis will continue to expand and effective therapeutic agents will be developed." | 2.71 | Interferon beta-1a in primary progressive multiple sclerosis. ( Leary, SM; Thompson, AJ, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 3 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Foley, P | 1 |
| Parker, RA | 4 |
| de Angelis, F | 3 |
| Connick, P | 3 |
| Chandran, S | 3 |
| Young, C | 1 |
| Weir, CJ | 4 |
| Chataway, J | 4 |
| Plantone, D | 3 |
| Doshi, A | 3 |
| John, N | 2 |
| Stutters, J | 3 |
| MacManus, D | 3 |
| Prados Carrasco, F | 2 |
| Barkhof, F | 4 |
| Ourselin, S | 2 |
| Braisher, M | 2 |
| Ross, M | 2 |
| Cranswick, G | 2 |
| Pavitt, SH | 2 |
| Giovannoni, G | 2 |
| Gandini Wheeler-Kingshott, CA | 2 |
| Hawkins, C | 2 |
| Sharrack, B | 2 |
| Bastow, R | 2 |
| Stallard, N | 2 |
| Solanky, BS | 1 |
| John, NA | 1 |
| DeAngelis, F | 1 |
| Prados, F | 1 |
| Schneider, T | 1 |
| Monteverdi, A | 1 |
| Marshall, I | 1 |
| Gandini Wheeler-Kingshott, CAM | 1 |
| Kalkers, NF | 1 |
| Bergers, E | 1 |
| van Schijndel, R | 1 |
| Polman, CH | 1 |
| Leary, SM | 1 |
| Thompson, AJ | 2 |
| Montalban, X | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-arm Phase IIB Randomised, Double Blind Placebo-controlled Clinical Trial Comparing the Efficacy of Three Neuroprotective Drugs in Secondary Progressive Multiple Sclerosis.[NCT01910259] | Phase 2 | 445 participants (Actual) | Interventional | 2014-12-18 | Completed | ||
| OxCarbazepine as a Neuroprotective Agent in MS: A Phase 2a Trial[NCT02104661] | Phase 2 | 30 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for riluzole and Chronic Progressive Multiple Sclerosis
| Article | Year |
|---|---|
Efficacy of Fluoxetine, Riluzole and Amiloride in treating neuropathic pain associated with secondary progressive multiple sclerosis. Pre-specified analysis of the MS-SMART double-blind randomised placebo-controlled trial.
Topics: Adult; Amiloride; Double-Blind Method; Fluoxetine; Humans; Multiple Sclerosis; Multiple Sclerosis, C | 2022 |
Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial.
Topics: Administration, Oral; Adult; Amiloride; Brain; Disease Progression; Double-Blind Method; Female; Flu | 2020 |
NAA is a Marker of Disability in Secondary-Progressive MS: A Proton MR Spectroscopic Imaging Study.
Topics: Adult; Amiloride; Aspartic Acid; Biomarkers; Child, Preschool; Cohort Studies; Cross-Sectional Studi | 2020 |
Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple scl
Topics: Adult; Amiloride; Double-Blind Method; Female; Fluoxetine; Humans; Male; Middle Aged; Multiple Scler | 2018 |
The effect of the neuroprotective agent riluzole on MRI parameters in primary progressive multiple sclerosis: a pilot study.
Topics: Adult; Aged; Atrophy; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclero | 2002 |
Interferon beta-1a in primary progressive multiple sclerosis.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Antineoplastic Agents; Disability Evaluation; Disease Pro | 2003 |
1 other study available for riluzole and Chronic Progressive Multiple Sclerosis
| Article | Year |
|---|---|
Workshop on primary progressive multiple sclerosis: meeting summary.
Topics: Adult; Clinical Trials as Topic; Cohort Studies; Diagnostic Imaging; Europe; Female; Genetic Predisp | 2002 |