riluzole has been researched along with Chemical and Drug Induced Liver Injury in 15 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Riluzole is the only disease-modifying drug approved for the treatment of amyotrophic lateral sclerosis (ALS), in which it has been demonstrated to extend survival." | 8.82 | The tolerability of riluzole in the treatment of patients with amyotrophic lateral sclerosis. ( Bensimon, G; Doble, A, 2004) |
| "Riluzole, a drug used in the management of amyotrophic lateral sclerosis (ALS), is associated with a high incidence of liver failure." | 7.96 | [Liver Injury Risk Factors in Amyotrophic Lateral Sclerosis Patients Treated with Riluzole]. ( Hirayama, T; Isozaki, Y; Kawano, C; Kuroyama, M; Nakagawa, A; Nishiyama, K, 2020) |
| "Riluzole is the only approved oral drug for amyotrophic lateral sclerosis (ALS)." | 7.91 | Interstitial pneumonia and other adverse events in riluzole-administered amyotrophic lateral sclerosis patients: a retrospective observational study. ( Aoki, M; Inoue-Shibui, A; Izumi, R; Kato, M; Kawauchi, Y; Kobayashi, J; Kuroda, H; Suzuki, N; Takai, Y; Warita, H, 2019) |
| "Riluzole is the only disease-modifying drug approved for the treatment of amyotrophic lateral sclerosis (ALS), in which it has been demonstrated to extend survival." | 4.82 | The tolerability of riluzole in the treatment of patients with amyotrophic lateral sclerosis. ( Bensimon, G; Doble, A, 2004) |
| "Riluzole, a drug used in the management of amyotrophic lateral sclerosis (ALS), is associated with a high incidence of liver failure." | 3.96 | [Liver Injury Risk Factors in Amyotrophic Lateral Sclerosis Patients Treated with Riluzole]. ( Hirayama, T; Isozaki, Y; Kawano, C; Kuroyama, M; Nakagawa, A; Nishiyama, K, 2020) |
| "Riluzole is the only approved oral drug for amyotrophic lateral sclerosis (ALS)." | 3.91 | Interstitial pneumonia and other adverse events in riluzole-administered amyotrophic lateral sclerosis patients: a retrospective observational study. ( Aoki, M; Inoue-Shibui, A; Izumi, R; Kato, M; Kawauchi, Y; Kobayashi, J; Kuroda, H; Suzuki, N; Takai, Y; Warita, H, 2019) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Trovafloxacin (Trovan) is a fluoroquinolone antibiotic drug with a long half-life and broad-spectrum activity." | 1.35 | In vitro metabolism of a model cyclopropylamine to reactive intermediate: insights into trovafloxacin-induced hepatotoxicity. ( Foss, FW; Macdonald, TL; Sun, Q; Zhu, R, 2008) |
| "Riluzole is a new drug representing the first active treatment for amyotrophic lateral sclerosis." | 1.30 | Acute hepatitis after riluzole administration. ( Blanc, P; Camu, W; Larrey, D; Ramos, J; Remy, AJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Kawano, C | 1 |
| Isozaki, Y | 1 |
| Nakagawa, A | 1 |
| Hirayama, T | 1 |
| Nishiyama, K | 1 |
| Kuroyama, M | 1 |
| Inoue-Shibui, A | 1 |
| Kato, M | 1 |
| Suzuki, N | 1 |
| Kobayashi, J | 1 |
| Takai, Y | 1 |
| Izumi, R | 1 |
| Kawauchi, Y | 1 |
| Kuroda, H | 1 |
| Warita, H | 1 |
| Aoki, M | 1 |
| Gordon, PH | 1 |
| Moore, DH | 1 |
| Gelinas, DF | 1 |
| Qualls, C | 1 |
| Meister, ME | 1 |
| Werner, J | 1 |
| Mendoza, M | 1 |
| Mass, J | 1 |
| Kushner, G | 1 |
| Miller, RG | 1 |
| Bensimon, G | 1 |
| Doble, A | 1 |
| Henderson, RD | 1 |
| McCombe, PA | 1 |
| Sun, Q | 1 |
| Zhu, R | 1 |
| Foss, FW | 1 |
| Macdonald, TL | 1 |
| Castells, LI | 1 |
| Gámez, J | 1 |
| Cervera, C | 1 |
| Guardia, J | 1 |
| Remy, AJ | 1 |
| Camu, W | 1 |
| Ramos, J | 1 |
| Blanc, P | 1 |
| Larrey, D | 1 |
2 reviews available for riluzole and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
The tolerability of riluzole in the treatment of patients with amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Asthenia; Biotransformation; Chemical and Drug Induced Liver In | 2004 |
1 trial available for riluzole and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Chemical and Drug Induced Liver Injury; Double-Blind Met | 2004 |
12 other studies available for riluzole and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
[Liver Injury Risk Factors in Amyotrophic Lateral Sclerosis Patients Treated with Riluzole].
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Chemical and Drug Induced Liver Injur | 2020 |
Interstitial pneumonia and other adverse events in riluzole-administered amyotrophic lateral sclerosis patients: a retrospective observational study.
Topics: Adult; Amyotrophic Lateral Sclerosis; Chemical and Drug Induced Liver Injury; Disease Progression; F | 2019 |
Riluzole: a glimmer of hope in the treatment of motor neurone disease.
Topics: Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Male; Middle Aged; Motor Neuron D | 2005 |
In vitro metabolism of a model cyclopropylamine to reactive intermediate: insights into trovafloxacin-induced hepatotoxicity.
Topics: Aldehydes; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Cross-Linking Reagents; Cy | 2008 |
Icteric toxic hepatitis associated with riluzole.
Topics: Aged; Amyotrophic Lateral Sclerosis; Chemical and Drug Induced Liver Injury; Female; Humans; Liver F | 1998 |
Acute hepatitis after riluzole administration.
Topics: Acute Disease; Aged; Chemical and Drug Induced Liver Injury; Excitatory Amino Acid Antagonists; Fema | 1999 |