riluzole has been researched along with Brain Ischemia in 13 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebral ischemia was induced by Middle Cerebral Artery Occlusion (MCAO) model for 1 h and NR was given intraperitoneally after 1 h of MCAO." | 5.43 | Enhancement in the Neuroprotective Power of Riluzole Against Cerebral Ischemia Using a Brain Targeted Drug Delivery Vehicle. ( Akhtar, M; Arora, I; Javed, K; Samim, M; Verma, SK, 2016) |
| " Striatum necrosis was not modified by the low dosage (46 +/- 3 mm3 versus 49 +/- 3 mm3 for control rats), whereas the high dosage increased it (61 +/- 3 mm3, P < 0." | 5.29 | Effect of riluzole on focal cerebral ischemia in rats. ( Allix, M; Boulu, RG; Plotkine, M; Wahl, F, 1993) |
| " Riluzole is used for the treatment of amyotrophic lateral sclerosis and reported to have neuroprotective effects in animal models of Parkinson's disease, Huntington's disease, and brain ischemia." | 3.72 | Riluzole enhances glutamate uptake in rat astrocyte cultures. ( Dalcin, KB; Dall'Onder, LP; Frizzo, ME; Souza, DO, 2004) |
| "Cerebral ischemia was induced by Middle Cerebral Artery Occlusion (MCAO) model for 1 h and NR was given intraperitoneally after 1 h of MCAO." | 1.43 | Enhancement in the Neuroprotective Power of Riluzole Against Cerebral Ischemia Using a Brain Targeted Drug Delivery Vehicle. ( Akhtar, M; Arora, I; Javed, K; Samim, M; Verma, SK, 2016) |
| "Neuronal death associated with cerebral ischemia and hypoglycemia is related to increased release of excitatory amino acids (EAA) and energy failure." | 1.33 | The anion channel blocker, 4,4'-dinitrostilbene-2,2'-disulfonic acid prevents neuronal death and excitatory amino acid release during glycolysis inhibition in the hippocampus in vivo. ( Camacho, A; Massieu, L; Montiel, T, 2006) |
| " Striatum necrosis was not modified by the low dosage (46 +/- 3 mm3 versus 49 +/- 3 mm3 for control rats), whereas the high dosage increased it (61 +/- 3 mm3, P < 0." | 1.29 | Effect of riluzole on focal cerebral ischemia in rats. ( Allix, M; Boulu, RG; Plotkine, M; Wahl, F, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (61.54) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Verma, SK | 1 |
| Arora, I | 1 |
| Javed, K | 1 |
| Akhtar, M | 1 |
| Samim, M | 1 |
| Frizzo, ME | 1 |
| Dall'Onder, LP | 1 |
| Dalcin, KB | 1 |
| Souza, DO | 1 |
| Li, ZB | 1 |
| Wang, XL | 1 |
| Camacho, A | 1 |
| Montiel, T | 1 |
| Massieu, L | 1 |
| Weng, YC | 1 |
| Kriz, J | 1 |
| Heurteaux, C | 1 |
| Lauritzen, I | 1 |
| Widmann, C | 1 |
| Lazdunski, M | 1 |
| Hebert, T | 1 |
| Drapeau, P | 1 |
| Pradier, L | 1 |
| Dunn, RJ | 1 |
| Wahl, F | 2 |
| Allix, M | 1 |
| Plotkine, M | 1 |
| Boulu, RG | 1 |
| O'Neill, MJ | 1 |
| Bath, CP | 1 |
| Dell, CP | 1 |
| Hicks, CA | 1 |
| Gilmore, J | 1 |
| Ambler, SJ | 1 |
| Ward, MA | 1 |
| Bleakman, D | 1 |
| Mottet, I | 1 |
| Demeure, R | 1 |
| Rataud, J | 2 |
| Lucas, M | 1 |
| Warscotte, V | 1 |
| Thiran, JP | 1 |
| Goudemant, JF | 1 |
| Maldague, B | 1 |
| Maloteaux, JM | 1 |
| Stutzmann, JM | 2 |
| Narahashi, T | 1 |
| Huang, CS | 1 |
| Song, JH | 1 |
| Yeh, JZ | 1 |
| Siniscalchi, A | 1 |
| Zona, C | 1 |
| Sancesario, G | 1 |
| D'Angelo, E | 1 |
| Zeng, YC | 1 |
| Mercuri, NB | 1 |
| Bernardi, G | 1 |
| Pratt, J | 1 |
| Bardot, F | 1 |
| Roux, M | 1 |
| Blanchard, JC | 1 |
| Laduron, PM | 1 |
2 reviews available for riluzole and Brain Ischemia
| Article | Year |
|---|---|
[Recent advances in the study of arachidonic acid-sensitive and mechano-gated tandem-pore-domain potassium channels--TREK].
Topics: Animals; Arachidonic Acid; Brain; Brain Ischemia; Female; Humans; Neuroprotective Agents; Ovary; Pot | 2006 |
Ion channels as targets for neuroprotective agents.
Topics: Animals; Brain Ischemia; Calcium Channels; GTP-Binding Proteins; Humans; Ion Channels; Neurons; Neur | 1997 |
11 other studies available for riluzole and Brain Ischemia
| Article | Year |
|---|---|
Enhancement in the Neuroprotective Power of Riluzole Against Cerebral Ischemia Using a Brain Targeted Drug Delivery Vehicle.
Topics: Animals; Brain; Brain Ischemia; Drug Delivery Systems; Male; Neuroprotective Agents; Rats; Rats, Wis | 2016 |
Riluzole enhances glutamate uptake in rat astrocyte cultures.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Ischemia; Cells, Cultured; Dose-Response Relationship, | 2004 |
The anion channel blocker, 4,4'-dinitrostilbene-2,2'-disulfonic acid prevents neuronal death and excitatory amino acid release during glycolysis inhibition in the hippocampus in vivo.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cell Death; Energy Metabolism; Excitatory Amino Acids; Exocy | 2006 |
Differential neuroprotective effects of a minocycline-based drug cocktail in transient and permanent focal cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Caspase 3; Drug Combinations; Enzyme Activation; Glial Fibrillary Ac | 2007 |
Glutamate-induced overexpression of NMDA receptor messenger RNAs and protein triggered by activation of AMPA/kainate receptors in rat hippocampus following forebrain ischemia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Base Sequence; Brain Ischemia; Excitatory Amino Acid | 1994 |
Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole.
Topics: Animals; Brain Ischemia; Models, Neurological; Neuropeptides; Oocytes; Rats; Riluzole; Sodium Channe | 1994 |
Effect of riluzole on focal cerebral ischemia in rats.
Topics: Anesthetics; Animals; Avoidance Learning; Blood Pressure; Brain; Brain Ischemia; Male; Rats; Rats, S | 1993 |
Effects of Ca2+ and Na+ channel inhibitors in vitro and in global cerebral ischaemia in vivo.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Calcium Channels; Cell Line; Dizocilpine Maleate; | 1997 |
Effects of riluzole on the evolution of focal cerebral ischemia: a magnetic resonance imaging study.
Topics: Animals; Brain; Brain Ischemia; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Rats; Rats | 1997 |
Neuroprotective effects of riluzole: an electrophysiological and histological analysis in an in vitro model of ischemia.
Topics: Animals; Brain Ischemia; Cell Count; Cell Death; Cell Survival; Dose-Response Relationship, Drug; El | 1999 |
Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Electroencephalography; Gerbillinae; Ischemic Attac | 1992 |