riluzole has been researched along with Brain Injuries in 8 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "According to the results of this study, riluzole appears to have a protective effect for sepsis-induced encephalopathy." | 7.75 | The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats. ( Ercan, F; Kabasakal, L; Kaya, M; Sirvanci, S; Toklu, HZ; Uysal, MK, 2009) |
| "According to the results of this study, riluzole appears to have a protective effect for sepsis-induced encephalopathy." | 3.75 | The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats. ( Ercan, F; Kabasakal, L; Kaya, M; Sirvanci, S; Toklu, HZ; Uysal, MK, 2009) |
| "Riluzole treatment did not modify the neurological status evaluated for the first 2 weeks after TBI." | 1.30 | Riluzole reduces brain lesions and improves neurological function in rats after a traumatic brain injury. ( Mary, V; Renou, E; Stutzmann, JM; Wahl, F, 1997) |
| "Our results demonstrate that (1) cerebral edema begins early after the injury and is resorbed over 1 week; (2) mannitol could attenuate cerebral edema; and (iii) riluzole in addition to its neuroprotective effects reduces the brain edema." | 1.30 | Time course of cerebral edema after traumatic brain injury in rats: effects of riluzole and mannitol. ( Bareyre, F; McIntosh, TK; Stutzmann, JM; Wahl, F, 1997) |
| "Treatment with Riluzole had no significant effect on posttraumatic lesion volume." | 1.29 | Riluzole, a novel neuroprotective agent, attenuates both neurologic motor and cognitive dysfunction following experimental brain injury in the rat. ( McIntosh, TK; Perri, BR; Smith, DH; Stutzmann, JM; Voddi, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Toklu, HZ | 1 |
| Uysal, MK | 1 |
| Kabasakal, L | 1 |
| Sirvanci, S | 1 |
| Ercan, F | 1 |
| Kaya, M | 1 |
| Risterucci, C | 1 |
| Coccurello, R | 1 |
| Banasr, M | 1 |
| Stutzmann, JM | 6 |
| Amalric, M | 1 |
| Nieoullon, A | 1 |
| McIntosh, TK | 3 |
| Smith, DH | 2 |
| Voddi, M | 1 |
| Perri, BR | 1 |
| Wahl, F | 4 |
| Renou, E | 1 |
| Mary, V | 1 |
| Bareyre, F | 1 |
| Zhang, C | 1 |
| Raghupathi, R | 1 |
| Saatman, KE | 1 |
| Stover, JF | 1 |
| Beyer, TF | 1 |
| Unterberg, AW | 1 |
8 other studies available for riluzole and Brain Injuries
| Article | Year |
|---|---|
The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats.
Topics: Animals; Blood-Brain Barrier; Body Temperature; Brain; Brain Edema; Brain Injuries; Cell Membrane Pe | 2009 |
The metabotropic glutamate receptor subtype 5 antagonist MPEP and the Na+ channel blocker riluzole show different neuroprotective profiles in reversing behavioral deficits induced by excitotoxic prefrontal cortex lesions.
Topics: Animals; Brain Injuries; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ibotenic | 2006 |
Riluzole, a novel neuroprotective agent, attenuates both neurologic motor and cognitive dysfunction following experimental brain injury in the rat.
Topics: Animals; Body Water; Brain Edema; Brain Injuries; Cognition Disorders; Male; Movement Disorders; Neu | 1996 |
Riluzole reduces brain lesions and improves neurological function in rats after a traumatic brain injury.
Topics: Animals; Brain; Brain Injuries; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sp | 1997 |
Time course of cerebral edema after traumatic brain injury in rats: effects of riluzole and mannitol.
Topics: Animals; Brain Edema; Brain Injuries; Cerebral Cortex; Diuretics, Osmotic; Functional Laterality; Hi | 1997 |
Riluzole attenuates cortical lesion size, but not hippocampal neuronal loss, following traumatic brain injury in the rat.
Topics: Animals; Brain Injuries; Cell Survival; Cerebral Cortex; Hippocampus; Male; Neurons; Neuroprotective | 1998 |
Neuroprotective effects of riluzole in neurotrauma models: a review.
Topics: Animals; Brain Edema; Brain Injuries; Cognition; Evoked Potentials, Somatosensory; Memory; Neurologi | 1999 |
Riluzole reduces brain swelling and contusion volume in rats following controlled cortical impact injury.
Topics: Animals; Body Water; Brain; Brain Edema; Brain Injuries; Cerebral Cortex; Glutamic Acid; Hypoxanthin | 2000 |