riluzole has been researched along with Brain Edema in 6 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "According to the results of this study, riluzole appears to have a protective effect for sepsis-induced encephalopathy." | 7.75 | The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats. ( Ercan, F; Kabasakal, L; Kaya, M; Sirvanci, S; Toklu, HZ; Uysal, MK, 2009) |
| "According to the results of this study, riluzole appears to have a protective effect for sepsis-induced encephalopathy." | 3.75 | The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats. ( Ercan, F; Kabasakal, L; Kaya, M; Sirvanci, S; Toklu, HZ; Uysal, MK, 2009) |
| "Our results demonstrate that (1) cerebral edema begins early after the injury and is resorbed over 1 week; (2) mannitol could attenuate cerebral edema; and (iii) riluzole in addition to its neuroprotective effects reduces the brain edema." | 1.30 | Time course of cerebral edema after traumatic brain injury in rats: effects of riluzole and mannitol. ( Bareyre, F; McIntosh, TK; Stutzmann, JM; Wahl, F, 1997) |
| "Treatment with mannitol at 3 g/kg i." | 1.30 | The effect of riluzole and mannitol on cerebral oedema after cryogenic injury in the mouse. ( Archambaud, C; Böhme, GA; Imperato, A; Pratt, J; Rataud, J; Roux, M; Stutzmann, JM, 1999) |
| "Treatment with Riluzole had no significant effect on posttraumatic lesion volume." | 1.29 | Riluzole, a novel neuroprotective agent, attenuates both neurologic motor and cognitive dysfunction following experimental brain injury in the rat. ( McIntosh, TK; Perri, BR; Smith, DH; Stutzmann, JM; Voddi, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Toklu, HZ | 1 |
| Uysal, MK | 1 |
| Kabasakal, L | 1 |
| Sirvanci, S | 1 |
| Ercan, F | 1 |
| Kaya, M | 1 |
| McIntosh, TK | 2 |
| Smith, DH | 1 |
| Voddi, M | 1 |
| Perri, BR | 1 |
| Stutzmann, JM | 4 |
| Bareyre, F | 1 |
| Wahl, F | 2 |
| Pratt, J | 1 |
| Archambaud, C | 1 |
| Böhme, GA | 1 |
| Roux, M | 1 |
| Rataud, J | 1 |
| Imperato, A | 1 |
| Stover, JF | 1 |
| Beyer, TF | 1 |
| Unterberg, AW | 1 |
6 other studies available for riluzole and Brain Edema
| Article | Year |
|---|---|
The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats.
Topics: Animals; Blood-Brain Barrier; Body Temperature; Brain; Brain Edema; Brain Injuries; Cell Membrane Pe | 2009 |
Riluzole, a novel neuroprotective agent, attenuates both neurologic motor and cognitive dysfunction following experimental brain injury in the rat.
Topics: Animals; Body Water; Brain Edema; Brain Injuries; Cognition Disorders; Male; Movement Disorders; Neu | 1996 |
Time course of cerebral edema after traumatic brain injury in rats: effects of riluzole and mannitol.
Topics: Animals; Brain Edema; Brain Injuries; Cerebral Cortex; Diuretics, Osmotic; Functional Laterality; Hi | 1997 |
Neuroprotective effects of riluzole in neurotrauma models: a review.
Topics: Animals; Brain Edema; Brain Injuries; Cognition; Evoked Potentials, Somatosensory; Memory; Neurologi | 1999 |
The effect of riluzole and mannitol on cerebral oedema after cryogenic injury in the mouse.
Topics: Animals; Brain Chemistry; Brain Edema; Brain Injury, Chronic; Diuretics, Osmotic; Freezing; Male; Ma | 1999 |
Riluzole reduces brain swelling and contusion volume in rats following controlled cortical impact injury.
Topics: Animals; Body Water; Brain; Brain Edema; Brain Injuries; Cerebral Cortex; Glutamic Acid; Hypoxanthin | 2000 |