Page last updated: 2024-11-03

riluzole and Aging

riluzole has been researched along with Aging in 7 studies

Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" The profile of inflammation-related genes and proteins associated with normal aging, or chronic neuroinflammation experimentally-induced via a four-week LPS infusion into the IV(th) ventricle, were correlated with performance in the Morris water maze following treatment with Riluzole, a drug that can enhance glutamate clearance by increasing GLT1 expression."3.79Riluzole partially rescues age-associated, but not LPS-induced, loss of glutamate transporters and spatial memory. ( Bardou, I; Brothers, HM; Corona, AW; Fenn, AM; Godbout, JP; Hopp, SC; Kaercher, RM; Wenk, GL, 2013)
"The neurodegenerative disorders (Parkinson's disease, Alzheimer's dementia, Huntington's disease, cerebellar degeneration) are common medical and social problems."2.40[Neurodegeneration: aging and dementia. Etiopathogenic role of electron transport disorders. Therapeutic possibilities]. ( Klivényi, P; Vécsei, L, 1997)
"Riluzole is known to increase the glutamate transporter EAAT2's ability to scavenge excess glutamate, regulating synaptic transmission."1.46Age and Alzheimer's disease gene expression profiles reversed by the glutamate modulator riluzole. ( Davidson, RL; Gray, JD; Kogan, JF; McEwen, BS; Morrison, JH; Okamoto, M; Pereira, AC; Rubin, TG, 2017)
"Riluzole was well tolerated upon repeat dose administration."1.30A comparison of the pharmacokinetics and tolerability of riluzole after repeat dose administration in healthy elderly and young volunteers. ( Cachia, JP; Gautier, JY; Groen, E; Guimart, C; Jonkman, JH; Kirkesseli, S; Le Liboux, A; Montay, G; Peeters, PA; Wemer, J, 1999)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (28.57)18.2507
2000's0 (0.00)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brothers, HM1
Bardou, I1
Hopp, SC1
Kaercher, RM1
Corona, AW1
Fenn, AM1
Godbout, JP1
Wenk, GL1
Pereira, AC2
Lambert, HK1
Grossman, YS1
Dumitriu, D1
Waldman, R1
Jannetty, SK1
Calakos, K1
Janssen, WG1
McEwen, BS2
Morrison, JH2
O'Connor, RM1
Moloney, RD1
Glennon, J1
Vlachou, S1
Cryan, JF1
Gray, JD1
Kogan, JF1
Davidson, RL1
Rubin, TG1
Okamoto, M1
Gajda, BM1
Fong, AY1
Milsom, WK1
Klivényi, P1
Vécsei, L1
Le Liboux, A1
Cachia, JP1
Kirkesseli, S1
Gautier, JY1
Guimart, C1
Montay, G1
Peeters, PA1
Groen, E1
Jonkman, JH1
Wemer, J1

Reviews

1 review available for riluzole and Aging

ArticleYear
[Neurodegeneration: aging and dementia. Etiopathogenic role of electron transport disorders. Therapeutic possibilities].
    Orvosi hetilap, 1997, Feb-09, Volume: 138, Issue:6

    Topics: Aged; Aging; Alzheimer Disease; Calcium Channel Blockers; Cerebellar Diseases; Dementia; Electron Tr

1997

Other Studies

6 other studies available for riluzole and Aging

ArticleYear
Riluzole partially rescues age-associated, but not LPS-induced, loss of glutamate transporters and spatial memory.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2013, Volume: 8, Issue:5

    Topics: Aging; Animals; Glutamate Plasma Membrane Transport Proteins; Hippocampus; Lipopolysaccharides; Maze

2013
Glutamatergic regulation prevents hippocampal-dependent age-related cognitive decline through dendritic spine clustering.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Dec-30, Volume: 111, Issue:52

    Topics: Aging; Animals; CA1 Region, Hippocampal; Cognition; Dendrites; Glutamic Acid; Male; Memory; Neuropro

2014
Enhancing glutamatergic transmission during adolescence reverses early-life stress-induced deficits in the rewarding effects of cocaine in rats.
    Neuropharmacology, 2015, Volume: 99

    Topics: Administration, Intravenous; Aging; Amino Acid Transport System X-AG; Animals; Cocaine; Cocaine-Rela

2015
Age and Alzheimer's disease gene expression profiles reversed by the glutamate modulator riluzole.
    Molecular psychiatry, 2017, Volume: 22, Issue:2

    Topics: Age Factors; Aging; Alzheimer Disease; Animals; Cognition; Cognitive Aging; Disease Models, Animal;

2017
Species differences in respiratory rhythm generation in rodents.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2010, Volume: 298, Issue:4

    Topics: Aging; Animals; Anti-Inflammatory Agents; Anticonvulsants; Brain Stem; Cricetinae; Flufenamic Acid;

2010
A comparison of the pharmacokinetics and tolerability of riluzole after repeat dose administration in healthy elderly and young volunteers.
    Journal of clinical pharmacology, 1999, Volume: 39, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Excitatory Amino Acid Antagonists; Female; Humans

1999