riluzole has been researched along with Aging in 7 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The profile of inflammation-related genes and proteins associated with normal aging, or chronic neuroinflammation experimentally-induced via a four-week LPS infusion into the IV(th) ventricle, were correlated with performance in the Morris water maze following treatment with Riluzole, a drug that can enhance glutamate clearance by increasing GLT1 expression." | 3.79 | Riluzole partially rescues age-associated, but not LPS-induced, loss of glutamate transporters and spatial memory. ( Bardou, I; Brothers, HM; Corona, AW; Fenn, AM; Godbout, JP; Hopp, SC; Kaercher, RM; Wenk, GL, 2013) |
| "The neurodegenerative disorders (Parkinson's disease, Alzheimer's dementia, Huntington's disease, cerebellar degeneration) are common medical and social problems." | 2.40 | [Neurodegeneration: aging and dementia. Etiopathogenic role of electron transport disorders. Therapeutic possibilities]. ( Klivényi, P; Vécsei, L, 1997) |
| "Riluzole is known to increase the glutamate transporter EAAT2's ability to scavenge excess glutamate, regulating synaptic transmission." | 1.46 | Age and Alzheimer's disease gene expression profiles reversed by the glutamate modulator riluzole. ( Davidson, RL; Gray, JD; Kogan, JF; McEwen, BS; Morrison, JH; Okamoto, M; Pereira, AC; Rubin, TG, 2017) |
| "Riluzole was well tolerated upon repeat dose administration." | 1.30 | A comparison of the pharmacokinetics and tolerability of riluzole after repeat dose administration in healthy elderly and young volunteers. ( Cachia, JP; Gautier, JY; Groen, E; Guimart, C; Jonkman, JH; Kirkesseli, S; Le Liboux, A; Montay, G; Peeters, PA; Wemer, J, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brothers, HM | 1 |
| Bardou, I | 1 |
| Hopp, SC | 1 |
| Kaercher, RM | 1 |
| Corona, AW | 1 |
| Fenn, AM | 1 |
| Godbout, JP | 1 |
| Wenk, GL | 1 |
| Pereira, AC | 2 |
| Lambert, HK | 1 |
| Grossman, YS | 1 |
| Dumitriu, D | 1 |
| Waldman, R | 1 |
| Jannetty, SK | 1 |
| Calakos, K | 1 |
| Janssen, WG | 1 |
| McEwen, BS | 2 |
| Morrison, JH | 2 |
| O'Connor, RM | 1 |
| Moloney, RD | 1 |
| Glennon, J | 1 |
| Vlachou, S | 1 |
| Cryan, JF | 1 |
| Gray, JD | 1 |
| Kogan, JF | 1 |
| Davidson, RL | 1 |
| Rubin, TG | 1 |
| Okamoto, M | 1 |
| Gajda, BM | 1 |
| Fong, AY | 1 |
| Milsom, WK | 1 |
| Klivényi, P | 1 |
| Vécsei, L | 1 |
| Le Liboux, A | 1 |
| Cachia, JP | 1 |
| Kirkesseli, S | 1 |
| Gautier, JY | 1 |
| Guimart, C | 1 |
| Montay, G | 1 |
| Peeters, PA | 1 |
| Groen, E | 1 |
| Jonkman, JH | 1 |
| Wemer, J | 1 |
1 review available for riluzole and Aging
| Article | Year |
|---|---|
[Neurodegeneration: aging and dementia. Etiopathogenic role of electron transport disorders. Therapeutic possibilities].
Topics: Aged; Aging; Alzheimer Disease; Calcium Channel Blockers; Cerebellar Diseases; Dementia; Electron Tr | 1997 |
6 other studies available for riluzole and Aging
| Article | Year |
|---|---|
Riluzole partially rescues age-associated, but not LPS-induced, loss of glutamate transporters and spatial memory.
Topics: Aging; Animals; Glutamate Plasma Membrane Transport Proteins; Hippocampus; Lipopolysaccharides; Maze | 2013 |
Glutamatergic regulation prevents hippocampal-dependent age-related cognitive decline through dendritic spine clustering.
Topics: Aging; Animals; CA1 Region, Hippocampal; Cognition; Dendrites; Glutamic Acid; Male; Memory; Neuropro | 2014 |
Enhancing glutamatergic transmission during adolescence reverses early-life stress-induced deficits in the rewarding effects of cocaine in rats.
Topics: Administration, Intravenous; Aging; Amino Acid Transport System X-AG; Animals; Cocaine; Cocaine-Rela | 2015 |
Age and Alzheimer's disease gene expression profiles reversed by the glutamate modulator riluzole.
Topics: Age Factors; Aging; Alzheimer Disease; Animals; Cognition; Cognitive Aging; Disease Models, Animal; | 2017 |
Species differences in respiratory rhythm generation in rodents.
Topics: Aging; Animals; Anti-Inflammatory Agents; Anticonvulsants; Brain Stem; Cricetinae; Flufenamic Acid; | 2010 |
A comparison of the pharmacokinetics and tolerability of riluzole after repeat dose administration in healthy elderly and young volunteers.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Excitatory Amino Acid Antagonists; Female; Humans | 1999 |