Page last updated: 2024-11-03

riluzole and Adult Spinal Muscular Atrophy

riluzole has been researched along with Adult Spinal Muscular Atrophy in 8 studies

Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.

Research Excerpts

ExcerptRelevanceReference
"Fourteen patients were enrolled in an open-label, nonrandomized and repeat-dose pharmacokinetic study."2.76Riluzole pharmacokinetics in young patients with spinal muscular atrophy. ( Abbara, C; Barois, A; Diquet, B; Estournet, B; Lacomblez, L; Lehmann, B; Lelièvre, B; Ouslimani, A; Viollet, L, 2011)
"Severe spinal muscular atrophy (SMA) (Werdnig-Hoffmann disease, acute SMA, and SMA I) is a disease of the motor neuron characterized by onset before 6 months of age, failure ever to achieve sitting without support, and a life expectancy of 2 years or less."2.71A phase 1 trial of riluzole in spinal muscular atrophy. ( Iannaccone, ST; Russman, BS; Samaha, FJ, 2003)
"The first clinical trials in spinal muscular atrophy are currently underway."2.40Carrell-Krusen Symposium invited lecture. Clinical trials in motor neuron diseases. ( Miller, RG, 1999)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's3 (37.50)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dimitriadi, M1
Kye, MJ1
Kalloo, G1
Yersak, JM1
Sahin, M1
Hart, AC1
Orrell, RW1
Abbara, C1
Estournet, B1
Lacomblez, L1
Lelièvre, B1
Ouslimani, A1
Lehmann, B1
Viollet, L1
Barois, A1
Diquet, B1
Cachia, D1
Izzy, S1
Ionete, C1
Salameh, J1
Pascuzzi, RM1
Haddad, H1
Cifuentes-Diaz, C1
Miroglio, A1
Roblot, N1
Joshi, V1
Melki, J1
Russman, BS1
Iannaccone, ST1
Samaha, FJ1
Miller, RG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Investigation of the Efficacy in Childhood Obsessive-Compulsive Disorder of Riluzole: An Antiglutamatergic Agent[NCT00251303]Phase 278 participants (Actual)Interventional2005-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Children's Yale-Brown Obsessive-Compulsive Scale Scores (CY-BOCS)

CY-BOCS is a 0-40 point scale of obsessive-compulsive symptom severity, higher number indicates more severe obsessive-compulsive symptoms. Comparison of 12 weeks scores for placebo and riluzole groups. (NCT00251303)
Timeframe: 12 weeks

Interventionunits on a scale (Mean)
Riluzole21.72
Placebo23.30

Much/Very Much Improved on Clinical Global Impressions - Improvement Score (CGI-I)

(NCT00251303)
Timeframe: 12 weeks

Interventionparticipants (Number)
Riluzole3
Placebo4

Reviews

3 reviews available for riluzole and Adult Spinal Muscular Atrophy

ArticleYear
Motor neuron disease: systematic reviews of treatment for ALS and SMA.
    British medical bulletin, 2010, Volume: 93

    Topics: Amyotrophic Lateral Sclerosis; Databases as Topic; Humans; Motor Neuron Disease; Muscular Atrophy, S

2010
ALS, motor neuron disease, and related disorders: a personal approach to diagnosis and management.
    Seminars in neurology, 2002, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Animals; Case Management; Combined Modality Therapy; Creatine; Diagnosis, Differe

2002
Carrell-Krusen Symposium invited lecture. Clinical trials in motor neuron diseases.
    Journal of child neurology, 1999, Volume: 14, Issue:3

    Topics: Acetates; Adolescent; Adult; Amines; Amyotrophic Lateral Sclerosis; Animals; Brain-Derived Neurotrop

1999

Trials

2 trials available for riluzole and Adult Spinal Muscular Atrophy

ArticleYear
Riluzole pharmacokinetics in young patients with spinal muscular atrophy.
    British journal of clinical pharmacology, 2011, Volume: 71, Issue:3

    Topics: Adolescent; Area Under Curve; Child; Dose-Response Relationship, Drug; Female; Humans; Male; Models,

2011
A phase 1 trial of riluzole in spinal muscular atrophy.
    Archives of neurology, 2003, Volume: 60, Issue:11

    Topics: Age of Onset; Child; Child, Preschool; Excitatory Amino Acid Antagonists; Humans; Infant; Infant, Ne

2003

Other Studies

3 other studies available for riluzole and Adult Spinal Muscular Atrophy

ArticleYear
The neuroprotective drug riluzole acts via small conductance Ca2+-activated K+ channels to ameliorate defects in spinal muscular atrophy models.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Apr-10, Volume: 33, Issue:15

    Topics: Animals; Axons; Caenorhabditis elegans; Cells, Cultured; Disease Models, Animal; Gene Knockdown Tech

2013
Brachial amyotrophic diplegia in the setting of complete HIV viral load suppression.
    BMJ case reports, 2012, Dec-06, Volume: 2012

    Topics: Antiretroviral Therapy, Highly Active; Arm; HIV Infections; Humans; Male; Middle Aged; Muscle Weakne

2012
Riluzole attenuates spinal muscular atrophy disease progression in a mouse model.
    Muscle & nerve, 2003, Volume: 28, Issue:4

    Topics: Animals; Axons; Cyclic AMP Response Element-Binding Protein; Cytoskeleton; Disease Progression; Gene

2003