rifamycin-sv and Postoperative-Complications

Topics: Actinomycetales; Actinomycetales Infections; Aged; Cataract; Ciprofloxacin; Corneal Edema; Corneal Ulcer; Drug Resistance, Multiple, Bacterial; Female; Fusidic Acid; Humans; Keratoplasty, Penetrating; Ointments; Ophthalmic Solutions; Postoperative Complications; Rifamycins; Tobramycin

A patient developed severe anaphylaxis during irrigation of a wound with rifamycin SV. The temporal relationship between application of rifamycin SV, the positive skin test and basophil activation test for rifamycin SV strongly supported diagnosis of anaphylaxis from the locally applied antibiotic. However, after operation the patient had two anaphylactic reactions with pruritus, urticaria and angio-oedema after routine care by a nurse, and these were probably caused by natural rubber latex. This case report has several messages. First, it is not widely appreciated that topically applied drugs and related compounds can elicit life-threatening anaphylaxis. Second, it illustrates patients can present with more than one allergy. Finally, it provides an opportunity to summarize the applications of flow cytometry-assisted quantification of in vitro activated basophils in diagnosing the cause of anaphylaxis during anaesthesia.

Topics: Administration, Topical; Adult; Anaphylaxis; Anti-Bacterial Agents; Drug Hypersensitivity; Humans; Intraoperative Complications; Latex Hypersensitivity; Male; Postoperative Complications; Rifamycins

Topics: Adolescent; Chloramphenicol; Cysts; Echinococcosis; Echinococcosis, Hepatic; Fever; Jaundice; Liver; Oxytetracycline; Pain; Penicillins; Postoperative Complications; Rifamycins; Sepsis; Streptomycin; Suppuration; Surgical Procedures, Operative

Topics: Cutaneous Fistula; Fistula; Hernia, Inguinal; Humans; Postoperative Complications; Rifamycins; Surgical Wound Infection

Topics: Chymotrypsin; Edema; Humans; Inflammation; Postoperative Complications; Rifamycins; Suppuration; Surgical Wound Infection; Thrombophlebitis; Trypsin