rifamycin-sv and Osteomyelitis

Actinomycosis is an uncommon chronic granulomatous infection that cause formation of abscesses and cutaneous fistula. In mandibular actinomycosis the alveolar bone and mandibular body are usually not involved and the pathogenetic mechanisms of the actinomycotic infiltration is unknown. The patients usually report pain at the alveolar arch with development of a purplish-red swelling firmly attached to the mandibula; the fibrous tissue produces the continued development of new cutaneous fistulas with oncoming pus-secretion. An uncommon case of actinomycotic osteomyelitis with a double pathological fracture of mandibula is reported. Ortopanoramic X-ray and computed tomography scan of the mandibula are effective and relevant diagnostic procedures to quantify the entity and site of the osteolitic areas and to define the precise position of fractures. In association with the intravenous infusion of benzilpenicillina, daily local irrigations of rifamicina have been performed. Moreover, the patient underwent surgical drainage of abscesses with accurate curettage of osteomyelitic lesions and several biopsies of the trabecolar bone and fistulas were taken. It has been also necessary to perform a mandibular blockage using a resinal plaque anchored on premolars. To reach a precise diagnosis, an histopathological examination togheter with batterioscopic-coltural examination is needed. Antibiotic therapy alone is not a sufficient therapeutic approach and surgical treatment must be quickly performed with clean up of the osteomyelitic lesions and contention of fractures by alveolar blockage for at least 40 days.

Topics: Abscess; Actinomycosis; Adult; Anti-Bacterial Agents; Biopsy; Ceftriaxone; Combined Modality Therapy; Cutaneous Fistula; Drainage; Drug Therapy, Combination; Fractures, Spontaneous; Humans; Male; Mandibular Fractures; Osteomyelitis; Penicillin G; Radiography, Panoramic; Rifamycins; Surgical Wound Infection; Tomography, X-Ray Computed; Tooth Extraction

Topics: Ankle; Child; Drug Resistance; Drug Resistance, Microbial; Femur; Humans; Metatarsus; Osteomyelitis; Radiography; Ribs; Rifamycins; Sepsis; Staphylococcal Infections; Tibia; Toxicology

Topics: Anti-Bacterial Agents; Calcaneus; Humans; Osteomyelitis; Rifamycins

Topics: Cellulitis; Injections, Intramuscular; Osteomyelitis; Rifamycins; Staphylococcal Infections; Streptococcal Infections; Suppuration; Toxicology

Topics: Anti-Bacterial Agents; Chlortetracycline; Dermatology; Drug Resistance; Drug Resistance, Microbial; Erythromycin; Gastroenterology; In Vitro Techniques; Kitasamycin; Leukemia; Methicillin; Novobiocin; Osteomyelitis; Otolaryngology; Penicillins; Pharmacology; Research; Respiratory Tract Infections; Rifamycins; Staphylococcus; Streptococcus; Urinary Tract Infections