rifampin and Uveitis--Anterior

Topics: Aged; Atrophy; Biopsy; Chronic Disease; Clofazimine; Dapsone; Drug Therapy, Combination; Eye Infections, Bacterial; Humans; Iris; Leprostatic Agents; Leprosy, Lepromatous; Macular Edema; Male; Mycobacterium leprae; Rifampin; Skin; Tomography, Optical Coherence; Uveitis, Anterior

Topics: Aged; Animals; Aqueous Humor; Cataract; Clinical Trials as Topic; Conjunctivitis; Cornea; Dacryocystitis; Eye Diseases; Glaucoma; Humans; Iritis; Keratitis; Middle Aged; Rabbits; Retinal Detachment; Retinitis; Rifampin; Uveitis, Anterior; Vitreous Body

In recent years, tuberculosis has re-emerged as a serious public health problem, raising the possibility that tuberculous eye disease may also have become more prevalent. Ocular tuberculosis usually occurs in apparently healthy individuals. It is rarely observed in patients with active pulmonary disease. An eight-year-old boy was admitted to our department because of chronic granulomatous anterior uveitis on his left eye. His medical history was unremarkable. There were no systemic symptoms of tuberculosis. He had a positive purified protein derivative test reaction. In our case, the diagnosis of ocular tuberculosis was presumptive and depended upon indirect evidence. The patient was started on anti-tuberculosis therapy with three drugs, which were continued for 12 months, with complete healing of the ocular lesions, including a marked improvement in the gait of the patient. Tuberculosis remains one of the most important causes of morbidity and mortality in developing countries.

Topics: Antibiotics, Antitubercular; Antitubercular Agents; Child; Granulomatous Disease, Chronic; Humans; Isoniazid; Male; Pyrazinamide; Rifampin; Tuberculosis, Ocular; Uveitis, Anterior

A 34-year-old man with a three-month history of intraocular inflammation after ocular trauma with a fir branch, had an acute unilateral fulminant iridocyclitis. The iris had a thick, gray, cheesy membrane composed of nodular lepromata. The patient denied a history of Hansen's disease, despite the dermatologic and facial features that suggested the diagnosis. Anterior chamber paracentesis and scleral nodule biopsy demonstrated Mycobacterium lepra. The iridocyclitis resolved after treatment with dapsone, corticosteroids, and rifampin.

Topics: Adult; Anterior Chamber; Atropine; Biopsy; Dapsone; Humans; Leprosy; Male; Prednisone; Punctures; Rifampin; Sclera; Triamcinolone; Uveitis, Anterior

Topics: Adult; Aged; Chorioretinitis; Choroiditis; Eye Diseases; Female; Humans; Male; Middle Aged; Optic Neuritis; Retinitis; Rifampin; Tuberculosis, Ocular; Uveitis; Uveitis, Anterior