rifampin and Urethritis

Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bacterial; Arthritis, Reactive; Azithromycin; Chlamydia Infections; Chlamydia trachomatis; Ciprofloxacin; Clinical Trials as Topic; Diagnosis, Differential; DNA, Bacterial; Drug Therapy, Combination; Enteritis; Female; Humans; Male; Models, Theoretical; Polymerase Chain Reaction; Rifampin; Salmonella; Salmonella Infections; Sensitivity and Specificity; Tetracyclines; Time Factors; Urethritis; Uterine Cervicitis; Yersinia; Yersinia Infections

Topics: Anti-Infective Agents, Urinary; Drug Combinations; Humans; Male; Oxytetracycline; Rifampin; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Urethritis

A total of 184 men with uncomplicated gonococcal urethritis were treated with a single oral dose of rifampicin 900 mg and erythromycin stearate 1 gm. The cure rate on day 3 was 95.1%, 175 were cured and 9 failed (4.9%). Of all the Neisseria gonorrhoeae isolated, 86 were PPNG (46.7%). There was no difference in failure rate among patients with PPNG or with non-PPNG. With the exception of self-limited gastrointestinal disturbance, side effects were minimal. The value of this combination for the treatment of uncomplicated gonococcal urethritis in men is promising and deserves further study.

Topics: Adolescent; Adult; Aged; Ampicillin; Clinical Trials as Topic; Costs and Cost Analysis; Drug Therapy, Combination; Erythromycin; Gonorrhea; Humans; Male; Middle Aged; Neisseria gonorrhoeae; Penicillin Resistance; Probenecid; Rifampin; Thailand; Urethritis

The results of a double-blind therapeutic trial on 217 men with nongonococcal urethritis (NGU) show that minocycline was more effective than rifampicin. Before treatment Chlamydia trachomatis was isolated from 43% of men, Ureaplasma urealyticum from 59%, and Mycoplasma hominis from 22%. Chlamydiae and ureaplasmas were isolated less frequently from men with a recent history of NGU. Minocycline was given to 94 patients, and after treatment chlamydiae were isolated from only one of 40 initially chlamydia-positive patients and ureaplasmas from only five of 57 initially ureaplasma-positive patients. Although most patients responded clinically, failure and partial recovery rather than complete recovery were observed more often among those who were infected with ureaplasmas. Rifampicin was given to 123 patients, after which chlamydiae were isolated from only one of 53 initially chlamydia-positive men whereas ureaplasmas, insensitive to the antibiotic in vitro, were isolated from 55 of 68 men who had initially positive results. Patients infected with ureaplasmas failed to respond to rifampicin treatment significantly more often than those who were not infected. This was also observed when only patients who had never had NGU or who had not had a recent episode were considered. Furthermore, 24 (44%) of the 55 men whose ureaplasmas persisted failed to recover whereas only one (7·7%) of 13 men whose ureaplasmas disappeared did not respond to treatment. These results suggested that ureaplasmas were a cause of urethritis in some of the men (an estimated 10% at least). In addition, Reiter's disease developed in two men treated with rifampicin from whom only ureaplasmas had been isolated initially. M. hominis did not seem to have an important pathogenic role in NGU and there was evidence that ureaplasmas were an unlikely cause of urethritis in some men since the organisms persisted despite complete clinical recovery.

Topics: Chlamydia trachomatis; Clinical Trials as Topic; Double-Blind Method; Humans; Male; Minocycline; Mycoplasma; Mycoplasma Infections; Rifampin; Ureaplasma; Urethritis

Topics: Clinical Trials as Topic; Gonorrhea; Humans; Male; Penicillin G Procaine; Penicillin Resistance; Rifampin; Syphilis; Tuberculosis; Uganda; Urethritis

Topics: Administration, Oral; Adolescent; Adult; Aged; Ampicillin; Clinical Trials as Topic; Cystitis; Female; Humans; Kidney Failure, Chronic; Male; Microbial Sensitivity Tests; Middle Aged; Prostatitis; Pyelonephritis; Rifampin; Urethritis; Urinary Tract Infections

To isolate bacteria, mycoplasma and chlamydia from the urogenital tract, and to determine their antibiotic susceptibility.. Bacteria, mycoplasma and chlamydia were isolated from the urogenital tract secretion by artifical culture, and their antibiotic susceptibility was detected by disk diffusion.. The common microorganisms were S. epidermidis and corynebacberium, and the minority microorganisms were G- bacteria or E. coli. Bacteria were susceptible to amikacin, cephazolin V, rifampin, gentamycin, and docycyclin.. S. epidermidis and corynebacterium are important pathogens of the urogenital tract infection. Disk susceptibility test can be used to screen the susceptible antibiotic.

Topics: Adult; Amikacin; Cefazolin; Chlamydia; Corynebacterium; Escherichia coli; Escherichia coli Infections; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Prostatitis; Rifampin; Staphylococcal Infections; Staphylococcus epidermidis; Urethritis; Uterine Cervicitis

Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Rifampin; Urethritis

Topics: Cefotaxime; Drug Therapy, Combination; Erythromycin; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Penicillinase; Rifampin; Urethritis

Topics: Acute Kidney Injury; Adult; Humans; Male; Rifampin; Urethritis

A total of 103 patients with acute gonococcal urethritis were treated with a single 1,200 mg dose of rifampicin. A 91 . 3% cure rate was obtained, as proved by the negative bacteriological controls effected on the 7th and 14th days after the initiation of therapy. Three pharyngeal infections and one ano-rectal infection responded successfully to the treatment. No signs of drug intolerance were detected with the stated dose. Reactivity to the VDRL test was not impaired during the duration of the study and three reactive cases were discovered. In previous studies of gonorrhoea we had observed a significant discrepancy between urine cultures and the urethral smears and, in view of this, it was decided to adopt the latter alone as a routine procedure. The proposed dose does not originate resistance to rifampicin in either the Hansen or Koch bacilli.

Topics: Drug Evaluation; Drug Tolerance; Gonorrhea; Humans; Male; Rifampin; Syphilis Serodiagnosis; Urethritis

Topics: Adolescent; Adult; Drug Evaluation; Gonorrhea; Humans; Male; Middle Aged; Rifampin; Time Factors; Urethra; Urethritis

The presence of allugtinins to the causative organism of contagious equine metritis (C.E.M.) in human serum has been confirmed. Agglutinins were found in the serum of 84 (37.6%) of 223 patients with non-gonococcal urethritis (N.G.U.), and in 12.5% of these patients there was a four-fold or greater rise in titre during the course of their illness. There was no evidence that these agglutinins were the result of infection by chlamydiae or ureaplasmas. Certain patients with these agglutinins seemed to respond better to therapy with antibiotics to which the C.E.M. bacterium is susceptible in vitro than did patients in whom these agglutinins were not found. The findings suggest that the C.E.M. bacterium or a microorganism related to it may be aetiologically involved in a proportion of patients with N.G.U. A search for such an organism in these patients is in progress.

Topics: Agglutination Tests; Agglutinins; Animals; Antibodies, Bacterial; Bacterial Infections; Endometritis; Female; Horse Diseases; Horses; Humans; In Vitro Techniques; Male; Minocycline; Rifampin; Urethritis

Topics: Adolescent; Adult; Gonorrhea; Humans; Male; Middle Aged; Rifampin; Urethritis

The therapeutic efficiency of benemycin (rifampicin of Polish production), a semisynthetic antibiotic was studied in 96 male cases with gonorrhea urethritis. The antibiotic was used in a dose of 300 mg every 6 hours (2.1--3gm for the treatment course depending on the desease severity). Observation of the patients for 1--2 months showed etiological recovery in 91 (94.8 per cent) out of 96 patients. Postgonorrhea inflammatory processes were observed in 8.7 per cent of the cases. For studying late results of the treatmant 62 patients were observed for 3 to 12 months. Gonococci were isolated from none of the patients. No side reactions were found in the patients treated with rifampicin.

Topics: Acute Disease; Adult; Drug Evaluation; Follow-Up Studies; Gonorrhea; Humans; Male; Rifampin; Time Factors; Urethritis

Topics: Bacterial Infections; Gonorrhea; Humans; Rifampin; Urethritis

Topics: Chancroid; Drug Combinations; Erythromycin; Female; Gonorrhea; Granuloma Inguinale; Humans; Injections, Intramuscular; Kanamycin; Lymphogranuloma Venereum; Male; Metronidazole; Penicillin Resistance; Penicillins; Rifampin; Sexually Transmitted Diseases; Streptomycin; Sulfamethoxazole; Sulfonamides; Syphilis; Tetracycline; Trimethoprim; Urethritis

Topics: Administration, Oral; Adolescent; Adult; Gonorrhea; Hospitalization; Humans; Injections, Intramuscular; Male; Outpatient Clinics, Hospital; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Rifampin; Urethritis

Topics: Administration, Oral; Adult; Gonorrhea; Humans; Male; Rifampin; Urethritis

Topics: Administration, Oral; Drug Hypersensitivity; Gonorrhea; Humans; Male; Penicillin Resistance; Rifampin; Urethritis

Topics: Animals; Dermatomycoses; Drug Resistance, Microbial; Enterobacteriaceae Infections; Guinea Pigs; Humans; Male; Microbial Sensitivity Tests; Prostatitis; Pyoderma; Rabbits; Rats; Rifampin; Skin Diseases, Infectious; Staphylococcal Infections; Streptococcal Infections; Urethritis; Urinary Tract Infections

Topics: Circadian Rhythm; Erythromycin; Humans; Male; Rifampin; Urethritis; Urinary Incontinence

Topics: Adolescent; Adult; Female; Gonorrhea; Humans; Male; Middle Aged; Rifampin; Urethritis; Vaginitis