rifampin and Tuberculosis--Oral

A case of primary tuberculosis of the tongue, an extremely rare entity is presented. The clinical manifestation, diagnosis and the response to antituberculous treatment are considered. The literature is also reviewed.

Topics: Adult; Antibiotics, Antitubercular; Antitubercular Agents; Diagnosis, Differential; Ethambutol; Follow-Up Studies; Humans; Isoniazid; Male; Pyrazinamide; Rifampin; Tongue Diseases; Tongue Neoplasms; Tuberculosis, Oral

Topics: Antibiotics, Antitubercular; Diagnosis, Differential; Drug Combinations; Ethambutol; Female; Humans; Middle Aged; Mycobacterium tuberculosis; Oral Ulcer; Pyrazinamide; Rifampin; Tuberculosis, Oral

A case of primary gingival tuberculosis in a 71-year-old Japanese woman is herein presented. A serous saliva culture was positive for tuberculosis, and we recognized that the origin of the tuberculosis infection was the gingiva based on the genetic identification in gingival biopsy tissue. The definitive diagnosis was facilitated by the genetic identification, a useful modern tool for diagnosing infectious diseases. The location and clinical presentation of this lesion were unusual, which underlines the importance of considering tuberculosis in the differential diagnosis of oral lesions that affect the gingiva.

Topics: Aged; Antitubercular Agents; Biopsy; Diagnosis, Differential; DNA, Bacterial; Ethambutol; Female; Gingival Diseases; Humans; Isoniazid; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Treatment Outcome; Tuberculosis, Oral

To highlight the importance of considering tuberculosis in the differential diagnosis even in the absence of confirmation from several investigations and diagnostic aides.. Tuberculosis is a common infectious granulomatous disease caused by various strains of mycobacteria. An oral lesion when seen in association with tuberculosis is very rare and in most cases is noticed secondary to pulmonary forms.. We report a case of primary gingival tuberculosis in 20-year-old female patient who presented with treatment resistant gingivitis. Patient had no evidence of disease elsewhere in the body and several diagnostic tests also failed to reveal the presence of the causative organism. Resolution of gingivitis was noted following a therapeutic trial of antitubercular drugs.. Therefore the importance of including tuberculosis in the differential diagnosis of inflammatory disorder of the gingiva is very essential in order to avoid one of the most lethal forms of infections often overlooked.. It is essential to consider tuberculosis as one of the differential diagnosis in India even when several diagnostic tests are negative for tuberculosis.

Topics: Antibiotics, Antitubercular; Antitubercular Agents; Diagnosis, Differential; Female; Gingival Diseases; Gingival Hemorrhage; Gingivitis; Humans; Isoniazid; Pyrazinamide; Rifampin; Tuberculosis, Oral; Young Adult

Tuberculosis (TB) is one of the leading casues of morbidity and death in a number of countries worldwide. A healthy 42-year-old patient presented with a chronic palatal ulcer that was not responsive to routine antibiotic treatment. A biopsy and further systemic investigation revealed a diagnosis of TB. An eight-month extended course of oral rifampin and isoniazid was instituted successfully resulting in complete resolution of symptoms. It is important that clinicians be aware that chronic oral ulcerations may be the first sign of systemic disease. A biopsy should therefore be mandatory for any chronic oral ulcer not responsive to conventional treatment.

Topics: Adult; Antitubercular Agents; Chronic Disease; Humans; Isoniazid; Male; Mouth Mucosa; Mycobacterium tuberculosis; Oral Ulcer; Rifampin; Treatment Outcome; Tuberculosis, Oral; Tuberculosis, Pulmonary

Tuberculosis remains an important public health problem in France. After a certain decline, its incidence has remained unchanged since 1990. 30% of tuberculosis cases are extra-pulmonary form, most of them concern nodes especially in cervical areas.. This case of submandibular tuberculosis illustrates diagnostic and therapeutic difficulties.. There are few clinical signs or laboratory clues suggestive of tuberculosis, however a surgery cannot be avoided and must be performed in combination with antituberculosis chemotherapy.

Topics: Antitubercular Agents; Combined Modality Therapy; Diagnosis, Differential; Ethambutol; Female; Humans; Isoniazid; Middle Aged; Pyrazinamide; Rifampin; Submandibular Gland Diseases; Tuberculosis, Oral

Tuberculosis (TB) is an infectious chronic disease. After decades of steadily declining prevalence, the disease has reemerged in the last 5 years. Symptoms of TB are mild and not specific and can be classified as either systemic or localized to target organs. Microscopic examination of the sputum remains an inexpensive and rapid way to identify highly infectious patients. Four different antimicrobial agents-rifampin, ethambutol, pirazinamide, and isoniazid-form the basis of currently recommended antituberculosis therapy. Tuberculosis could be an occupational risk for health care workers. Dentists must be involved in the health promotion and early detection of TB.

Topics: Adult; Antitubercular Agents; Child; Dental Staff; Ethambutol; Humans; Infectious Disease Transmission, Patient-to-Professional; Isoniazid; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Tuberculosis, Oral; Tuberculosis, Pulmonary

Topics: Adult; Alveolar Bone Loss; Diagnosis, Differential; Drug Therapy, Combination; Ethambutol; Female; Humans; Isoniazid; Maxillary Diseases; Pyrazinamide; Rifampin; Tuberculosis, Oral

Tuberculosis, and non-tuberculous mycobacterial infections are becoming more common thus it is more likely that otolaryngologists will encounter these conditions. We describe an otherwise well patient, with symptoms and signs from chronic uvular inflammation, who proved to have a primary mycobacterial infection. This is an unique presentation in the literature and reminds clinicians of the need, where uncertainty exists in diagnosis, to consider mycobacterial infections.

Topics: Adult; Antibiotics, Antitubercular; Antitubercular Agents; Combined Modality Therapy; Humans; Male; Pyrazinamide; Pyridoxine; Rifampin; Tuberculosis, Oral; Uvula

Primary tuberculosis in the oral cavity is a rare entity. Usually, the microorganisms need a disruption of the oral mucosa to become pathogenic. In this article the authors describe a clinical case of primary oral tuberculosis, on a female of 52 years-old who suffered an exodontia 20 days before. The bacteria identificated was Mycobacterium tuberculosis hominis. The microbiologic identification is essential to assure the efficacy of the treatment.

Topics: Antibiotics, Antitubercular; Antitubercular Agents; Drug Therapy, Combination; Female; Humans; Isoniazid; Middle Aged; Mouth Mucosa; Mycobacterium tuberculosis; Pyrazinamide; Radiography, Panoramic; Rifampin; Time Factors; Tooth Extraction; Tuberculosis, Oral

A 4-year-old child with probable multifocal BCG osteomyelitis is reported. The lesions in the skull, clavicula, humerus, ribs, fibula, calcaneus, metatarsus, and hard palate were mainly osteolytic and healed rapidly with antituberculotic therapy. This is the first time that involvement of the hard palate has been described.

Topics: Antibiotics, Antitubercular; Antitubercular Agents; BCG Vaccine; Child, Preschool; Humans; Isoniazid; Male; Mycobacterium tuberculosis; Osteomyelitis; Palate; Rifampin; Tuberculosis, Oral; Tuberculosis, Osteoarticular

A patient with Hodgkin's disease (HD) underwent autologous bone marrow transplantation (ABMT). Six months later while receiving interleukin (IL)-2 and alpha-interferon immunotherapy, he developed a painful lesion in his oral cavity with a fistula in the buccal area. Excision biopsy disclosed necrotizing granulomatous inflammation with acid-fast bacillus. The patient received a 9-month course of isoniazide, rifampin and pyrazinamide, and recovered. The possible pathophysiological mechanism is discussed.

Topics: Adjuvants, Immunologic; Adult; Anti-Bacterial Agents; Antitubercular Agents; Bone Marrow Transplantation; Combined Modality Therapy; Disease Susceptibility; Drug Therapy, Combination; Fistula; Hodgkin Disease; Humans; Immunocompromised Host; Interferon-alpha; Interleukin-2; Isoniazid; Male; Opportunistic Infections; Oral Ulcer; Pyrazinamide; Recombinant Proteins; Rifampin; Risk Factors; Transplantation Conditioning; Transplantation, Autologous; Tuberculosis, Oral

Oral tuberculosis with pulmonary tuberculosis is very rare in Japan. A 45-year old man admitted to our hospital because of spontaneous teeth extraction and pain in oral cavity for the past 3 months. The painful granulation in palate and fistel of 7th tooth root defect in right upper gum were observed. The diagnosis of oral tuberculosis was made by the histological examination of biopsy material and positive smear test for M. tuberculosis in surface of granulation. Chest X-ray showed multicavitary lesions in bilateral upper lobs and spread shadows in bilateral lower lung fields. He was treated with chemotherapy (INH, RFP, SM and EB) and with tube feeding. Five month's chemotherapy was needed to achieve cured granulation and negative smear test for M. tuberculosis in sputum. He was discharged 10 months after admission.

Topics: Diagnosis, Differential; Drug Therapy, Combination; Humans; Isoniazid; Male; Middle Aged; Mycobacterium tuberculosis; Rifampin; Streptomycin; Tuberculosis, Oral

A 44-year-old man, a heavy smoker over many years, complained of hoarseness for 8 weeks with weight loss and dysphagia. Malignant tumour of the pharynx was suspected. Examination revealed a swelling of the right upper lip, tumorous changes in the right buccal mucosa, about 6 x 6 cm in size, as well as enlargement of the cervical lymph-nodes. Microlaryngoscopy revealed a three-level tumour of the entire side of the right larynx. Histological examination of biopsies of the right false and true vocal cords as well as the buccal mucosa demonstrated numerous, partly caseous epithelioid granulomas with Langhans giant cells. Ziehl-Neelsen staining showed acid-fast rods. Combined tuberculostatic treatment with isoniazid, rifampicin, ethambutol and pyrazinamide achieved regression of all signs and symptoms within two months. This case emphasizes the need for including laryngeal tuberculosis in the differential diagnosis of seemingly malignant laryngeal tumours.

Topics: Adult; Diagnosis, Differential; Drug Therapy, Combination; Endoscopy; Ethambutol; Humans; Isoniazid; Male; Pharyngeal Diseases; Pharyngeal Neoplasms; Pyrazinamide; Rifampin; Tuberculosis; Tuberculosis, Laryngeal; Tuberculosis, Oral

A 26 year-old female was seeking treatment for a painless ulcerated lesion of the tongue developing 30 days before. No history of a sef biting in that area was told by the patient. Following a provisional diagnosis of tuberculous ulcer or a neoplasm, under local anesthesia, a segment of the lesion was excised and sent to histological diagnosis, which confirmed the existence of a tuberculous ulcer. Additionally, a chest roentgenogram disclosed the presence of an undiagnosed pulmonar tuberculous lesion. The patient underwent a successful treatment with rifampicin, isoniazide and pirazinamide, and two month after the initial diagnosis the oral lesion was almost absent, although the pulmonar lesion was still detected on the roentgenogram. Finally, a total disappearance of the pulmonar lesion was detected six month following drug treatment.

Topics: Adult; Female; Humans; Isoniazid; Pyrazinamide; Rifampin; Tongue Diseases; Tuberculosis; Tuberculosis, Oral; Tuberculosis, Pulmonary; Ulcer

Topics: Ethambutol; Humans; Isoniazid; Lung; Male; Middle Aged; Mouth Mucosa; Radiography; Rifampin; Tongue Diseases; Tuberculosis; Tuberculosis, Oral

Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Humans; Isoniazid; Liver; Male; Parotid Diseases; Rifampin; Tuberculosis; Tuberculosis, Oral

Topics: Aged; Diagnosis, Differential; Epiglottis; Esophageal Neoplasms; Hospitals, General; Humans; Ileocecal Valve; Isoniazid; Laryngeal Neoplasms; Laryngoscopy; Male; Otitis Media; Pharyngitis; Radiography; Respiratory Tract Infections; Rifampin; Tongue Diseases; Tonsillitis; Tuberculosis; Tuberculosis, Gastrointestinal; Tuberculosis, Laryngeal; Tuberculosis, Oral; Tuberculosis, Pulmonary