rifampin and Tonsillitis

Therapeutic effect of liposomal dosages of rifampicin and prodigiozan was studied on rabbits with simulated chronic tonsillitis in comparison to that of commercial ones of the drugs. The treatment schemes included daily intra-tonsillar++ injections of the dosage forms for 5 days. A high efficacy of their liposomal dosage forms in treatment of experimental chronic tonsillitis was confirmed microbiologically and immunologically. Approval of the liposomal dosage forms used in the therapy of patients with chronic tonsillitis requires clinical trials.

Topics: Adjuvants, Immunologic; Animals; Chronic Disease; Drug Carriers; Drug Evaluation, Preclinical; Drug Therapy, Combination; Liposomes; Palatine Tonsil; Polysaccharides, Bacterial; Prodigiozan; Rabbits; Rifampin; Streptococcal Infections; Tonsillitis

The Neisseria species with which most otolaryngologists are familiar is N gonorrhoeae, which can cause acute pharyngitis or tonsillitis. Less well known is N meningitidis, responsible for potentially fatal meningococcal meningitis and meningococcemia. Although present in the carrier state in the pharynx of asymptomatic individuals, N meningitidis previously has not been associated with symptomatic pharyngeal or tonsillar disease. Its isolation from a patient with acute tonsillitis and failure to eliminate the symptoms and organism with penicillin led to use of rifampin. Disappearance of sore throat following use of this antibiotic and inability at completion of therapy to isolate the organism from a homogenate of excised tonsil would appear to implicate the organism as a cause of acute pharyngeal and tonsillar infection. It should be added to the list of organisms capable of producing acute tonsillitis, and rifampin should be considered a chemotherapeutic agent.

Topics: Adult; Humans; Male; Neisseria meningitidis; Palatine Tonsil; Rifampin; Tonsillitis

Topics: Aged; Diagnosis, Differential; Epiglottis; Esophageal Neoplasms; Hospitals, General; Humans; Ileocecal Valve; Isoniazid; Laryngeal Neoplasms; Laryngoscopy; Male; Otitis Media; Pharyngitis; Radiography; Respiratory Tract Infections; Rifampin; Tongue Diseases; Tonsillitis; Tuberculosis; Tuberculosis, Gastrointestinal; Tuberculosis, Laryngeal; Tuberculosis, Oral; Tuberculosis, Pulmonary

Topics: Adolescent; Adult; Aerosols; Ampicillin; Anti-Bacterial Agents; Bacteria; Child; Chronic Disease; Depression, Chemical; Erythromycin; Erythromycin Ethylsuccinate; Humans; Injections, Intramuscular; Iontophoresis; Methacycline; Methicillin; Middle Aged; Neomycin; Oleandomycin; Oxacillin; Palatine Tonsil; Penicillin Resistance; Rifampin; Saliva; Staphylococcus; Streptococcus; Tetracycline; Time Factors; Tonsillitis

Topics: Abscess; Adult; Aged; Female; Humans; Male; Middle Aged; Respiratory Tract Infections; Rifampin; Tonsillitis; Tuberculosis; Urinary Tract Infections