rifampin and Sporotrichosis

We report a case of Mycobacterium marinum facial sporotrichoid infection in an otherwise healthy 2-year-old child, probably acquired through contact with pets in an aquarium. The M. marinum isolate was susceptible to clarithromycin, and the child was successfully treated with oral antibiotic therapy. This unusual case emphasizes the importance of a thorough history in the evaluation of a patient with chronic sporotrichoid skin lesions.

Topics: Administration, Oral; Anti-Bacterial Agents; Child, Preschool; Chronic Disease; Clarithromycin; Diagnosis, Differential; Drug Therapy, Combination; Facial Dermatoses; Humans; Male; Mycobacterium Infections, Nontuberculous; Rifampin; Sporotrichosis

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antitubercular Agents; Bacteriological Techniques; Clarithromycin; Diagnosis, Differential; Drug Therapy, Combination; Ethambutol; Humans; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Rifampin; Skin Diseases, Bacterial; Sporotrichosis

The Authors describe two cases of Sporotrichoid infection characterized by the onset, above previous skin accidental injuries, of a papulo-pustular lesion, with further development of centripetal satellite lesions similar to the first one. A precise etiological definition was possible only after the cultural,l mycological and bacteriological examination of biopsy material. The very similar clinical features of the two cases were due to different etiological pathogens: Sporothrix schenckii in one case and Mycobacterium marinum in the other case. A complete healing of the skin lesion was obtained with Itraconazole in the first case and Rifampin in the second case.

Topics: Aged; Biopsy; Diagnosis, Differential; Female; Humans; Itraconazole; Ketoconazole; Male; Middle Aged; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Rifampin; Skin Diseases, Infectious; Sporothrix; Sporotrichosis

Four cases of chronic granulomatous skin infections (two due to Sporothrix schenckii and two to Mycobacterium marinum) were treated primarily by the intermittent application of local hyperthermia. This treatment was initiated either because of intolerance to conventional iodide therapy for sporotrichosis or as interim therapy while awaiting diagnosis of the mycobacterial infections. The response indicated that the application of heat is a useful adjunct to the therapy of these infections. Our experience, and that of others, suggests that in some cases heat alone may be curative.

Topics: Adult; Aged; Chronic Disease; Ethambutol; Female; Granuloma; Hot Temperature; Humans; Iodides; Male; Middle Aged; Mycobacterium Infections, Nontuberculous; Rifampin; Skin Diseases, Infectious; Sporotrichosis