rifampin and Splenic-Diseases

Splenic abscess due to acute brucellosis is a rare event. We report a case of multiple splenic abscesses caused by Brucella melitensis in a 45-year-old woman and review the English language literature based on a PubMed/MEDLINE search of the last 50 years. The majority of the cases published in the literature were due to B. melitensis and a splenectomy was required in half of the cases. Antibiotics alone without surgical intervention can be successful in the treatment of patients with splenic brucellosis in the early stages of the disease.

Topics: Abdominal Abscess; Administration, Oral; Anti-Bacterial Agents; Brucella melitensis; Brucellosis; Doxycycline; Female; Humans; Middle Aged; Rifampin; Splenectomy; Splenic Diseases; Treatment Outcome

The case of a woman with splenic abscess due to Brucella is reported. There was no response with antibiotics and surgical treatment was required. On the basis of this case and the literature review we consider that surgical treatment must be considered in patients with splenic abscess due to Brucella infection.

Topics: Adult; Anti-Bacterial Agents; Brucellosis; Doxycycline; Drug Therapy, Combination; Female; Humans; Rifampin; Serologic Tests; Splenectomy; Splenic Diseases; Splenomegaly; Streptomycin

We reviewed 19 cases of hepatosplenic cat-scratch disease at Texas Children's Hospital (Houston). The range of the patients' ages was 2 years 4 months to 11 years 8 months. The chief complaint was fever for all patients. The duration of fever before diagnosis was 7 to 56 days (mean, 22 days). Abdominal pain was present in 13 patients (68%). Thirteen children were treated with rifampin alone, and three received rifampin therapy plus gentamicin or trimethoprim-sulfamethoxazole. Once rifampin therapy was initiated alone or in combination, improvement was noted within 1 to 5 days (mean, 2.6 days) for patients who had had prolonged fever the duration of which before rifampin therapy averaged 3 weeks. The most common dosage and duration for our patients were 20 mg/[kg x d] every 12 hours and 14 days, respectively. Rifampin should be considered in the initial antimicrobial treatment of hepatosplenic cat-scratch disease.

Topics: Animals; Anti-Bacterial Agents; Cat-Scratch Disease; Cats; Child; Child, Preschool; Humans; Liver Diseases; Rifampin; Splenic Diseases

Infections caused by

Topics: Adult; Anti-Bacterial Agents; Antitubercular Agents; Clarithromycin; Diagnosis, Differential; Ethambutol; Granuloma; Humans; Immunocompromised Host; Male; Mycobacterium avium Complex; Polymerase Chain Reaction; Rifampin; Spleen; Splenic Diseases

Splenic abscess due to Brucella spp. is extremely rare. We report a case of a splenic abscess due to Brucella spp. in a 61-year-old male patient. Brucella slide and tube agglutination tests (Wright) were positive while blood culture and culture from splenic tissue yielded negative results. The abdominal ultrasonography revealed a hypoechoic intrasplenic mass 15x12 mm in diameter at the middle portion of the spleen. The splenic lesions disappeared after prolonged treatment for 7 months with a combination of doxycycline, and rifampicin, followed by TMP-SXT. Brucella spp. should be considered in the differential diagnosis of splenic abscess in countries where brucellosis is endemic. The results of this case and literature review shows that a conservative approach using optimum antibiotics alone without surgical intervention can be successful in the treatment of patients with splenic brucellosis.

Topics: Abdominal Abscess; Agglutination Tests; Anti-Infective Agents; Brucellosis; Doxycycline; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Male; Middle Aged; Rifampin; Spleen; Splenic Diseases; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination; Ultrasonography

Topics: Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Bartonella henselae; Cat-Scratch Disease; Cats; Child; Humans; Liver Diseases; Male; Rifampin; Splenic Diseases; Treatment Outcome

Brucellosis may lead to complications that affect different organ systems, including the liver and spleen. In acute disease, hepatosplenic abscess is a rare complication. We report herein a woman with splenic abscess due to acute Brucella melitensis infection who was successfully treated with antibiotics alone.

Topics: Abdominal Abscess; Aged; Anti-Bacterial Agents; Brucella melitensis; Brucellosis; Doxycycline; Female; Humans; Rifampin; Splenic Diseases; Streptomycin

Topics: Antibiotics, Antitubercular; Cat-Scratch Disease; Child; Child, Preschool; Diagnosis, Differential; Fever of Unknown Origin; Humans; Liver Abscess; Male; Rifampin; Spleen; Splenic Diseases; Ultrasonography

Topics: Antibodies, Bacterial; Cat-Scratch Disease; Child, Preschool; Female; Fluorescent Antibody Technique; Follow-Up Studies; Humans; Liver Diseases; Rickettsieae; Rifampin; Splenic Diseases

A thrush-like oral infection with subsequent alveolar abscess formation and a positive blood culture due to Trichosporon capitatum developed in a patient with acute myelogenous leukaemia. Later T. capitatum was identified by indirect immunofluorescence in multiple splenic abscesses. The infection was controlled by immediate aggressive treatment with amphotericin B, flucytosine and rifampicin and by splenectomy. This case of systemic T. capitatum infection resembles somewhat the invasive mycosis due to candida.

Topics: Abscess; Adult; Amphotericin B; Blood; Female; Flucytosine; Humans; Leukemia, Myeloid, Acute; Mitosporic Fungi; Mycoses; Rifampin; Splenic Diseases

Topics: Adolescent; Adrenal Cortex Hormones; Anemia; Antibodies; BCG Vaccine; Biopsy; Bone Marrow Diseases; Ethambutol; Female; Fever; Hepatomegaly; Humans; Immunity, Cellular; Immunoglobulins; Immunologic Deficiency Syndromes; Iron; Isoniazid; Leukocyte Count; Lymph Nodes; Lymphocytes; Lymphopenia; Mycobacterium bovis; Mycobacterium Infections; Rifampin; Splenic Diseases; Splenomegaly; Tuberculin Test

Topics: Animals; Antitubercular Agents; Guinea Pigs; Isoniazid; Lung Diseases; Lymph Nodes; Mycobacterium tuberculosis; Organ Size; Rifampin; Skin Ulcer; Spleen; Splenic Diseases; Tuberculin Test; Tuberculosis