rifampin and Skin-Neoplasms

Topics: Antitubercular Agents; BCG Vaccine; Carcinoma, Squamous Cell; Child; Ethambutol; Humans; Isoniazid; Lupus Vulgaris; Lymphatic Metastasis; Male; Pyrazinamide; Rifampin; Skin Neoplasms; Treatment Outcome

Human brucellosis is a multisystemic infectious disease with a broad spectrum of clinical manifestations. Severe complications involving musculoskeletal, nervous, genitourinary, and cardiovascular systems may be encountered during the course of the disease; however, cutaneous complications have been reported rarely. We report a patient with brucellosis in whom the main presenting clinical feature was a maculopapular rash and fever. He was initially diagnosed as brucellosis based on the standard tube agglutination test and blood culture positivity. Histopathologic examination of these maculopapular lesions showed perivascular and periadnexal inflammation with loose granuloma formation including giant cells. We emphasize that brucellosis is an infectious disease that should always be kept in mind in the differential diagnosis of a patient with rash and fever, especially in endemic areas.

Topics: Agglutination Tests; Anti-Bacterial Agents; Antihypertensive Agents; Brucellosis; Diagnosis, Differential; Doxycycline; Drug Therapy, Combination; Duodenal Ulcer; Exanthema; Humans; Hypertension; Lymphoma, T-Cell, Cutaneous; Male; Middle Aged; Rifampin; Skin Neoplasms

Topics: Adult; Antibiotics, Antitubercular; False Positive Reactions; Foot Diseases; Humans; Male; Melanins; Melanoma; Rifampin; Skin Neoplasms

A patient with mycosis fungoides that had progressed to tumor stage responded to chemotherapy and electron beam treatment, but 6 years later a peripheral neuropathy, extensive plaques, erythroderma, and enlarged pinnae containing acid-fast organisms developed while he was being treated with photopheresis. The skin lesions cleared with administration of rifampin and dapsone, but a reversal reaction biopsy specimen showed features of both mycosis fungoides and leprosy. This case raises the question of whether there may be an association between mycosis fungoides and leprosy.

Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dapsone; Humans; Leprosy, Lepromatous; Male; Middle Aged; Mycosis Fungoides; Photopheresis; Rifampin; Skin Diseases, Bacterial; Skin Neoplasms