rifampin and Skin-Diseases--Vascular

Infective endocarditis is associated with a variety of clinical signs, but its association with multisystem vasculitis is rarely reported. A high index of suspicion is necessary to differentiate a primary autoimmune vasculitis from an infectious cause as the wrong treatment can lead to significant morbidity and mortality. We present a 71-year-old female patient with negative blood cultures, on antibiotics for recent bacteraemia, who presented with cutaneous and renal leucocytoclastic vasculitis. Workup revealed a vegetation adjacent to her right atrial pacemaker lead consistent with infective endocarditis and her vasculitis completely resolved with appropriate antibiotics.

Topics: Acute Kidney Injury; Aged; Anti-Bacterial Agents; Antibodies, Antineutrophil Cytoplasmic; Bacteremia; Ceftriaxone; Endocarditis, Bacterial; Female; Humans; Pulmonary Edema; Renal Dialysis; Respiratory Insufficiency; Rifampin; Skin Diseases, Vascular; Staphylococcal Infections; Vasculitis

Topics: Antibiotics, Antitubercular; Antitubercular Agents; Ethambutol; Humans; Isoniazid; Male; Middle Aged; Mycobacterium tuberculosis; Rifampin; Skin Diseases, Vascular; Tuberculosis, Pulmonary; Vasculitis, Leukocytoclastic, Cutaneous

Topics: Adult; Female; Glomerulonephritis; Humans; Rifampin; Skin Diseases, Vascular; Vasculitis