rifampin and Purpura--Thrombocytopenic

Topics: Adolescent; Adult; Age Factors; Aged; Drug Administration Schedule; Drug Therapy, Combination; Female; Fever; Humans; Isoniazid; Leukocytosis; Lymphopenia; Male; Middle Aged; Purpura, Thrombocytopenic; Rifampin; Sex Factors; Tuberculosis, Pulmonary

Topics: Acute Kidney Injury; Anaphylaxis; Anemia, Hemolytic; Dose-Response Relationship, Drug; Drug Hypersensitivity; Humans; Hypotension; Purpura, Thrombocytopenic; Rifampin

Topics: Aminosalicylic Acids; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cycloserine; Drug Resistance, Microbial; Drug Synergism; Drug Tolerance; Hemorrhagic Disorders; Humans; Isoniazid; Kanamycin; Phenylthiourea; Purpura, Thrombocytopenic; Pyrazines; Recurrence; Rifampin; Streptomycin; Tuberculosis, Pulmonary

Topics: Clinical Trials as Topic; Drug Hypersensitivity; Drug Therapy, Combination; Ethambutol; Fever; Gastrointestinal Diseases; Humans; Jaundice; Purpura, Thrombocytopenic; Respiratory Insufficiency; Rifampin; Skin Manifestations; Time Factors; Tuberculosis, Pulmonary

Topics: Clinical Trials as Topic; Drug Therapy, Combination; Female; Fever; Gastrointestinal Diseases; Headache; Humans; Isoniazid; Male; Purpura, Thrombocytopenic; Rifampin; Time Factors; Tuberculosis, Pulmonary

Topics: Antibody Formation; Clinical Trials as Topic; Drug Resistance, Microbial; Drug Therapy, Combination; Ethambutol; Humans; Isoniazid; Kidney Function Tests; Liver Function Tests; Purpura, Thrombocytopenic; Recurrence; Rifampin; Time Factors; Tuberculosis, Pulmonary

Topics: Adult; Animals; Antibody Formation; Antigen-Antibody Reactions; Clinical Trials as Topic; Female; Fever; Headache; Humans; Immune Tolerance; Male; Mice; Middle Aged; Purpura, Thrombocytopenic; Rabbits; Rats; Rifampin; Tuberculosis, Pulmonary

Topics: Antibody Formation; Binding Sites, Antibody; Blood Cell Count; Clinical Trials as Topic; Erythrocytes; Female; Humans; Iproniazid; Isoniazid; Leukocyte Count; Male; Purpura, Thrombocytopenic; Rifampin; Tuberculosis, Pulmonary

We report the case of a 28-year-old resident doctor with no past history of having taken rifampicin, who presented with thrombocytoapaenic purpura occurring after the initiation of anti-tuberculosis therapy (isoniazid, rifampicin, pyrazinamide and ethambutol) for tubercular lymphadenopathy.

Topics: Adult; Antibiotics, Antitubercular; Humans; Lymph Nodes; Male; Mediastinum; Purpura, Thrombocytopenic; Radiography, Thoracic; Rifampin; Treatment Outcome; Tuberculosis, Pulmonary; Withholding Treatment

Drug-induced immune thrombocytopenia (DITP) can be triggered by a wide range of medications. Although many cases of DITP are mild, some are characterised by life-threatening bleeding symptoms. In the treatment of tuberculosis there are special therapeutic problems related to adverse effects of drugs, compliance to treatment and microbial resistance. Thrombocytopenia is an uncommon but potentially fatal adverse effect of certain antituberculous drugs when the incriminating drug is taken by a susceptible individual. Here the authors report a case of rifampicin-induced thrombocytopenia, which although rare, needs attention.

Topics: Adult; Antibiotics, Antitubercular; Diagnosis, Differential; Female; Humans; Pleural Effusion; Purpura, Thrombocytopenic; Rifampin

Two children who presented with fever, thrombocytopenic purpura and mucosal haemorrhages proved to have brucellosis. Large platelets in the peripheral smear and megakaryocytic hyperplasia in the bone marrow suggested increased peripheral destruction as the primary mechanism of the thrombocytopenia. There was a prompt clinical and haematological response to specific anti-brucella chemotherapy. The nature of this association and its implications for brucella-endemic areas are discussed.

Topics: Acute Disease; Blood Platelets; Bone Marrow; Brucellosis; Child; Child, Preschool; Diagnosis, Differential; Drug Therapy, Combination; Female; Gentamicins; Humans; Male; Megakaryocytes; Platelet Count; Purpura, Thrombocytopenic; Rifampin; Saudi Arabia; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Aged; Autoantibodies; Blood Platelets; Humans; Male; Platelet Count; Purpura, Thrombocytopenic; Rifampin; Tuberculosis, Pulmonary

Topics: Female; Humans; Meningitis, Meningococcal; Middle Aged; Purpura, Thrombocytopenic; Rifampin

From 8 cases of immuno-allergic accidents attributed to Rifampicine, the authors review the literature on the subject. The "flue like" syndrome is the most frequent and characteristic of those accidents, worsened by haematological and renal involvements. These accidents probably belong to a pathology of immuno-complexes in relaiton with the production of anti-Rifampicine antibodies. Among the different means of in vitro diagnosis, the test with the anti-complement antiglobulin is the most reliable, though not always in good correlation with clinical signs. Though rare and most often benign, these accidents should lead to prudence in treating recurrent tuberculosis or reusing Rifampicine after a momentary interruption.

Topics: Aged; Antibodies; Drug Hypersensitivity; Female; Humans; Purpura, Thrombocytopenic; Respiratory Tract Diseases; Rifampin; Skin Diseases; Tuberculosis, Pulmonary

Topics: Acute Kidney Injury; Adolescent; Cycloserine; Drug Therapy, Combination; Dyspnea; Ethambutol; Ethionamide; Fever; Follow-Up Studies; Headache; Humans; Purpura, Thrombocytopenic; Pyrazinamide; Rifampin; Time Factors; Tuberculosis, Pulmonary

Topics: Antibody Formation; Antigen-Antibody Reactions; Drug Therapy, Combination; Fever; Headache; Humans; Isoniazid; Nausea; Purpura, Thrombocytopenic; Pyridoxine; Rifampin; Streptomycin; Tuberculosis, Pulmonary

Topics: Adult; Cells, Cultured; Cerebral Hemorrhage; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Ethambutol; Female; Humans; Male; Purpura, Thrombocytopenic; Rifampin; Sputum; Time Factors; Tuberculosis, Pulmonary

Topics: Ambulatory Care; Drug Therapy, Combination; Ethambutol; Female; Headache; Humans; Male; Nausea; Purpura, Thrombocytopenic; Rifampin; Tuberculosis, Pulmonary; Vomiting

Topics: Body Weight; Drug Therapy, Combination; Ethambutol; Female; Fever; Headache; Humans; Male; Nausea; Pain; Purpura, Thrombocytopenic; Rifampin; Time Factors; Tuberculosis, Pulmonary; Vomiting

Topics: Acute Kidney Injury; Antibodies; Drug Therapy, Combination; Ethambutol; Fever; Headache; Hemorrhage; Humans; Liver Function Tests; Nausea; Purpura, Thrombocytopenic; Rifampin; Time Factors; Tuberculosis, Pulmonary

Topics: Acute Kidney Injury; Adult; Bilirubin; Biopsy; Creatinine; Female; Humans; Kidney; Kidney Function Tests; Male; Middle Aged; Purpura, Thrombocytopenic; Rifampin; Transaminases; Tuberculosis, Pulmonary

Topics: Antibody Formation; Blood Cell Count; Blood Platelets; Cerebral Hemorrhage; Dyspnea; Ethambutol; Humans; Immunoglobulins; Liver Function Tests; Male; Middle Aged; Prednisone; Purpura, Thrombocytopenic; Rifampin; Tuberculosis, Pulmonary

Topics: Antibody Formation; Coombs Test; Female; Humans; Male; Purpura, Thrombocytopenic; Rifampin; Tuberculosis, Pulmonary

Topics: Aged; Humans; Male; Purpura, Thrombocytopenic; Rifampin; Thrombocytopenia

Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Azathioprine; Cephalosporins; Humans; Liver Abscess, Amebic; Metronidazole; Purpura, Thrombocytopenic; Respiratory Tract Infections; Rifampin; Sarcoidosis; Urinary Tract Infections

Topics: Adult; Aged; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Purpura, Thrombocytopenic; Rifampin; Thrombocytopenia; Tuberculosis, Pulmonary