rifampin and Poultry-Diseases

Experimental infection studies were carried out on the ability of three Clostridium perfringens type A rifampicin-resistant strains to colonize the intestinal tract of broiler chickens kept in isolators from 1-day-old. Various doses of C. perfringens were given orally at 22 days, 9 days or at 1 day old. At 22 days none of the strains, given in doses of approximately 10(10) colony-forming units, caused mortality or clinical necrotic enteritis. None was able to colonize the intestine permanently and all were eliminated within 9 days. One strain given to groups of 9-day-old birds was recovered only from those receiving high doses, but for no longer than 13 days. In chicks infected at 1-day-old there was transient colonization up to 15 days, and the most persistent colonization was in a group given a fresh broth culture of unwashed cells, including extracellular products. Test strains were rapidly replaced by naturally occurring strains of C. perfringens in all groups but they persisted for considerably longer in chickens inoculated at 1-day-old or at 9 days than those at 22 days, indicating a possible resistance to colonization with increasing age. The findings emphasize the difficulties of establishing a reproducible model for infection with C. perfringens in broiler chickens.

Topics: Animals; Anti-Bacterial Agents; Chickens; Clostridium Infections; Clostridium perfringens; Drug Resistance, Bacterial; Female; Housing, Animal; Male; Poultry Diseases; Rifampin

To estimate the prevalence of antibiotic resistance in indicator bacteria Escherichia coli and Enterococci isolated from duck faeces in Morogoro Municipality, Tanzania.. Escherichia coli and Enterococcus isolation rates from ducks faeces were 91 and 100% respectively. The prevalence of antibiotic resistance of E. coli and Enterococcus was 70.3 and 42%, respectively. E. coli resistant to four antibiotics were 28 (30.8%) and showed high resistance to ampicillin (81.3), tetracycline (75.8) and trimethoprim-sulphamethoxine (62.3). Multiple antibiotic resistance of Enterococcus were more than 65%. High resistance rates shown by Enterococcus were observed in rifampin (62%), ampicillin (62%) and tetracycline (42%). Almost all farmers (92.3%) left their ducks to scavenge for food around their houses. Antibiotics used in animal treatments were oxytetracyclines, sulfonamides, penicillin dihydrostreptomycin while in humans were tetracycline, ampicillin, and amoxicillin.

Topics: Ampicillin; Animals; Anti-Bacterial Agents; Asymptomatic Diseases; Drug Resistance, Multiple, Bacterial; Ducks; Enterococcus; Escherichia coli; Escherichia coli Infections; Feces; Female; Humans; Male; Microbial Sensitivity Tests; Poultry; Poultry Diseases; Rifampin; Streptococcal Infections; Tanzania; Tetracycline; Trimethoprim, Sulfamethoxazole Drug Combination