rifampin and Phlebitis

A 22-year-old woman presented with recurrent non-ulcerating skin nodules overlying the great saphenous vein on the anteromedial lower legs. Histology showed a granulomatous phlebitis, and polymerase chain reaction performed on lesional skin detected DNA specific for Mycobacterium tuberculosis. The lesions resolved with anti-tuberculous therapy. This case may be a further example of nodular granulomatous phlebitis, a phlebitic tuberculid.

Topics: Adult; Antitubercular Agents; Diagnosis, Differential; Female; Granuloma; Humans; Isoniazid; Mycobacterium tuberculosis; Panniculitis; Phlebitis; Rifampin; Treatment Outcome; Tuberculosis, Cutaneous

Topics: Adult; Anti-Bacterial Agents; Cellulitis; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neutropenia; Phlebitis; Polymyxin B; Pseudomonas aeruginosa; Pseudomonas Infections; Rifampin; Treatment Outcome

Topics: Aged; Arthritis, Infectious; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Autoimmune Diseases; Ciprofloxacin; Cloxacillin; Drug Therapy, Combination; Fatal Outcome; Humans; Immunocompromised Host; Knee Prosthesis; Male; Phlebitis; Postoperative Complications; Prosthesis-Related Infections; Pulmonary Embolism; Recurrence; Rifampin; Staphylococcal Infections; Staphylococcus; Virulence

Brucellosis is hyperendemic in Saudi Arabia where, despite rapid urbanisation, a large segment of the population has a nomadic background and clings to cultural traditions such as the drinking of raw milk. We report here an unusual complication of brucellosis in a microbiology technologist. A 41-year-old male presented with an 8-day history of right ankle pain which, over a 3-day period, extended up to his calf where swelling and tightness developed. The leg symptomatology occurred on a background of fever, seats and rigors. X-ray of the limb was normal but a venogram revealed thrombosis of the deep veins of the right calf. Although his blood culture was negative, he developed high brucella antibody titres. Treatment with anticoagulants combined with a course of doxycycline and rifampin produced a full recovery.

Topics: Adult; Anti-Bacterial Agents; Antibodies, Bacterial; Anticoagulants; Brucella abortus; Brucella melitensis; Brucellosis; Diagnosis, Differential; Doxycycline; Enzyme Inhibitors; Humans; Male; Occupational Exposure; Phlebitis; Rifampin