rifampin and Paralysis

rifampin has been researched along with Paralysis* in 3 studies

Other Studies

3 other study(ies) available for rifampin and Paralysis

ArticleYear
Rifampin-associated tubulointersititial nephritis and Fanconi syndrome presenting as hypokalemic paralysis.
    BMC nephrology, 2013, Jan-16, Volume: 14

    Rifampin is one of the most important drugs in first-line therapies for tuberculosis. The renal toxicity of rifampin has been reported sporadically and acute tubulointerstitial nephritis (ATIN) is a frequent histological finding. We describe for the first time a case of ATIN and Fanconi syndrome presenting as hypokalemic paralysis, associated with the use of rifampin.. A 42-year-old man was admitted with sudden-onset lower extremity paralysis and mild renal insufficiency. He had been treated for pulmonary tuberculosis with isoniazid, rifampin, and ethambutol for 2 months. Laboratory tests revealed proteinuria, profound hypokalemia, hyperchloremic metabolic acidosis with a normal anion gap, positive urine anion gap, hypophosphatemia with hyperphosphaturia, hypouricemia with hyperuricosuria, glycosuria with normal serum glucose level, generalized aminoaciduria, and β2-microglobulinuria. A kidney biopsy revealed findings typical of ATIN and focal granular deposits of immunoglubulin A and complement 3 in the glomeruli and tubules. Electron microscopy showed epithelial foot process effacement and electron-dense deposits in the subendothelial and mesangial spaces. Cessation of rifampin resolved the patient's clinical presentation of Fanconi syndrome, and improved his renal function and proteinuria.. This case demonstrates that rifampin therapy can be associated with Fanconi syndrome presenting as hypokalemic paralysis, which is a manifestation of ATIN. Kidney function and the markers of proximal tubular injury should be carefully monitored in patients receiving rifampin.

    Topics: Adult; Antibiotics, Antitubercular; Diagnosis, Differential; Fanconi Syndrome; Humans; Hypokalemia; Male; Nephritis, Interstitial; Paralysis; Rifampin

2013
A child with neurobrucellosis.
    Annals of tropical paediatrics, 2003, Volume: 23, Issue:2

    An 11-year-old boy presented with chronic meningitis followed by acute flaccid paralysis. The aetiology remained uncertain until the brucellar serology test became positive and there was a good response to specific antimicrobial therapy. Nerve conduction studies confirmed a proximal radiculopathy. Awareness of the condition and performance of the appropriate tests will differentiate neurobrucellosis from other chronic central nervous system infections.

    Topics: Anti-Bacterial Agents; Brucellosis; Central Nervous System Bacterial Infections; Child; Chronic Disease; Doxycycline; Humans; Male; Meningitis, Bacterial; Neural Conduction; Paralysis; Radiculopathy; Rifampin

2003
Management of virus cental nervous system disease.
    British medical journal, 1969, Dec-06, Volume: 4, Issue:5683

    Topics: Chronic Disease; Coma; Dactinomycin; Daunorubicin; Dexamethasone; Encephalomyelitis; Fever; Headache; Humans; Idoxuridine; Leukopenia; Meningitis, Viral; Mental Disorders; Pain; Paralysis; Respiratory Insufficiency; Rifampin; Vomiting

1969