rifampin and Pancreatic-Diseases

Two patients with a history of intravenous drug abuse developed a pancreatic abscess due to mycobacterial infection as their initial evident opportunistic infection in association with the acquired immunodeficiency syndrome (AIDS). This presentation of mycobacterial infection has been previously reported in nine patients. The two patients reported here are the second and third reported cases in association with AIDS. As this entity should be considered a cause of a pancreatic lesion in immunosuppressed patients, fluid drained from a pancreatic abscess should have histologic stains and cultures for mycobacteria.

Topics: Abscess; Acquired Immunodeficiency Syndrome; Adult; Amikacin; Female; Gentamicins; Humans; Isoniazid; Middle Aged; Mycobacterium Infections; Nafcillin; Pancreatic Diseases; Penicillins; Rifampin; Tomography, X-Ray Computed; Ultrasonography

Topics: Aged; Antitubercular Agents; Biopsy, Fine-Needle; Diagnosis, Differential; Drug Therapy, Combination; Ethambutol; Female; Humans; Isoniazid; Pancreatic Diseases; Pancreatic Neoplasms; Pyrazinamide; Rifampin; Tomography, X-Ray Computed; Tuberculosis

Tuberculosis of the pancreas is very rare and can present with many signs and symptoms, including obstructive jaundice, weight loss and a mass in the head of the pancreas. Hence the diagnosis of pancreatic tuberculosis remains a challenge and a high index of suspicion is required. If a tumour is suspected then an ultrasound- or CT-guided fine needle aspiration should be performed. Even if the initial microbiological results are negative, using conventional techniques, PCR can yield more rapid results and avoid an unnecessary laparotomy.

Topics: Adult; Biopsy, Needle; Diagnosis, Differential; Ethambutol; Humans; Isoniazid; Male; Pancreas; Pancreatic Diseases; Rifampin; Tomography, X-Ray Computed; Tuberculosis

Topics: Ethambutol; Female; Humans; Immunosuppression Therapy; Isoniazid; Kidney Failure, Chronic; Kidney Transplantation; Middle Aged; Pancreatic Diseases; Postoperative Complications; Rifampin; Transplantation, Homologous; Tuberculosis