rifampin and Muscular-Diseases

Topics: Aged, 80 and over; Anemia; Antibiotics, Antitubercular; Anticoagulants; Drug Interactions; Hematoma; Humans; Male; Muscular Diseases; Polypharmacy; Rifampin; Risk; Warfarin

Brucellosis may show itself only through its bone and muscle complications, especially in the lumbar region, such as vertebral colliquation or psoas abscess. The authors describe a case of brucellosis (56 year old male, butcher) with lumbar bone and muscle involvement. The first symptom was a persistent pain of the right lumbar region, with irradiation to the homolateral leg. At admission the patient showed a lumbar cutaneous fistula with pus-like secretion. Quick diagnosis and therapy can prevent irreparable damage, even when the symptoms are silent.

Topics: Animals; Anti-Bacterial Agents; Bone Diseases; Brucellosis; Cattle; Diagnosis, Differential; Doxycycline; Humans; Ilium; Lumbar Vertebrae; Male; Middle Aged; Muscular Diseases; Psoas Muscles; Rifampin; Therapeutic Irrigation

A case of psoas abscess occurring during treatment of tuberculous lymphadenopathy is described. There was no evidence of a bony origin for this abscess. It appears likely that it arose from involved glands on the posterior abdominal wall.

Topics: Abscess; Adult; Drug Therapy, Combination; Ethambutol; Humans; Isoniazid; Male; Muscular Diseases; Retroperitoneal Space; Rifampin; Time Factors; Tuberculosis, Lymph Node

The authors report two cases of muscular tuberculosis in patients with dermatomyositis treated with steroids. Antituberculous therapy with Rifampicin led to a severe relapse of the dermatomyositis in both cases, suggesting enzymatic induction inhibiting the action of the steroids.

Topics: Adrenal Cortex Hormones; Dermatomyositis; Humans; Male; Middle Aged; Muscular Diseases; Recurrence; Rifampin; Tuberculosis

The effect of acute administration of rifampicin on neuromuscular transmission was tested, in-vivo, in the rat. Rifampicin did not alter the strength of contraction of the muscle indirectly stimulated at various frequencies. Additional isoniazid pretreatment did not alter the absence of effect of rifampicin on neuromuscular action.

Topics: Animals; Male; Muscular Diseases; Neuromuscular Junction; Rats; Rats, Inbred Strains; Rifampin

Topics: Adult; Female; Humans; Muscular Diseases; Mycobacterium Infections, Nontuberculous; Rifampin; Tuberculosis, Pulmonary