rifampin and Movement-Disorders

A retrospective descriptive assessment of the clinical and radiologic outcomes of 11 patients who underwent transpedicular decompression for thoracic spine tuberculosis.. To study the neurologic and radiologic outcomes in patients who underwent transpedicular decompression for thoracic spine tuberculosis.. Several approaches have been used in the management of thoracic spine tuberculosis to achieve the goals of decompression of the cord followed by immobilization and antituberculous therapy. These range from conservative regimens of computed tomography-guided biopsy followed by bed rest and drug therapy to radical surgeries that involve extensive debridement of the vertebral body followed by instrumentation. The authors report their experience with a "middle path" regimen of transpedicular decompression followed by external immobilization and antituberculous therapy.. The charts of 11 patients were reviewed retrospectively for clinical outcome, and kyphotic angle was measured on the follow-up radiographs to ascertain progression of kyphosis.. There was no worsening of the neurologic status in any patient, and 10 of the 11 patients returned to functional activity. There was no significant progression of kyphosis.. Our results show that the transpedicular approach is a viable and safe surgical option for ventral decompression in thoracic spine tuberculosis, followed by chemotherapy for 18 months and immobilization in an alkathene shell for 3 months.

Topics: Abscess; Adolescent; Adult; Aged; Antitubercular Agents; Braces; Combined Modality Therapy; Curettage; Debridement; Decompression, Surgical; Disease Progression; Drainage; Ethambutol; Female; Follow-Up Studies; Humans; Immobilization; Isoniazid; Kyphosis; Male; Middle Aged; Movement Disorders; Pyrazinamide; Radiography; Recovery of Function; Retrospective Studies; Rifampin; Severity of Illness Index; Spinal Cord Compression; Thoracic Vertebrae; Treatment Outcome; Tuberculosis, Spinal