rifampin and Mandibular-Diseases

Methicillin-resistant Staphylococcus aureus (MRSA) is a type of Staphylococcus that is resistant to certain antibiotics, such as methicillin, oxacillin, penicillin, and amoxicillin. This nosocomial pathogen has become a great threat in hospitals globally. Up to 40% of the normal population carries S. aureus in the anterior nares, and this rate is often higher in hospitalized patients and their attendants. This case report presents a patient with serious MRSA osteomyelitis of the mandible demonstrating purulent discharge. The patient failed to recover despite prolonged postoperative treatment and the administration of several antibiotics. There was a resulting nonunion along with chronic MRSA infection. The treatment protocol involved a multimodal approach with parenteral clindamycin infusion, local rifampicin irrigation, and intermaxillary fixation of the jaws.

Topics: Adult; Anti-Bacterial Agents; Bone Plates; Clindamycin; Fracture Fixation, Internal; Humans; Infusions, Intralesional; Male; Mandibular Diseases; Mandibular Fractures; Methicillin-Resistant Staphylococcus aureus; Osteomyelitis; Prosthesis-Related Infections; Reoperation; Rifampin; Staphylococcal Infections; Therapeutic Irrigation; Treatment Outcome

Topics: Adult; Amikacin; Anti-Bacterial Agents; Clarithromycin; Drug Resistance, Bacterial; Female; Humans; Mandibular Diseases; Mycobacterium chelonae; Mycobacterium Infections, Nontuberculous; Osteomyelitis; Rifampin; Root Canal Therapy

Topics: Biopsy; Diagnosis, Differential; Ethambutol; Female; Humans; Isoniazid; Mandibular Diseases; Middle Aged; Rifampin; Sarcoidosis; Tuberculosis, Osteoarticular