rifampin and Macular-Edema

Topics: Aged; Atrophy; Biopsy; Chronic Disease; Clofazimine; Dapsone; Drug Therapy, Combination; Eye Infections, Bacterial; Humans; Iris; Leprostatic Agents; Leprosy, Lepromatous; Macular Edema; Male; Mycobacterium leprae; Rifampin; Skin; Tomography, Optical Coherence; Uveitis, Anterior

Topics: Adolescent; Anti-Bacterial Agents; Bartonella henselae; Cat-Scratch Disease; Diagnosis, Differential; Doxycycline; Female; Follow-Up Studies; Humans; Macular Edema; Retinitis; Rifampin; Vision Disorders; Visual Acuity

To describe an infrequent presentation of ocular tuberculosis.. Retrospective observational case report.. A 61-year-old woman presented with decreased vision in her right eye and cystoid macular edema resistant to periocular corticosteroid treatment. There were no other findings.. Diagnosis of probable underlying tuberculosis uveitis with macular edema as the only ocular manifestation was established based on a clinical history of possible tuberculosis during her infancy. Additionally, there were residual findings in the patient's chest x-ray, a positive Mantoux reaction, and Mycobacterium tuberculosis in sputum. Specific treatment was implemented for nine months. Cystoid macular edema resolved completely, visual acuity improved (20/20), and no remission occurred during two years of follow-up.. In cases of idiopathic cystoid macular edema, tuberculosis should be considered as a potential cause. When treated, both are curable.

Topics: Antitubercular Agents; Drug Therapy, Combination; Ethambutol; Female; Humans; Isoniazid; Macular Edema; Middle Aged; Mycobacterium tuberculosis; Retrospective Studies; Rifampin; Sputum; Tuberculin Test; Tuberculosis, Ocular

A healthy 57 year-old woman with past untreated pulmonary tuberculosis, disclosed a bilateral uveitic syndrome characte rized by iritis, vitreitis, multiple peripheral retinal punched-out lesions, and cystoid macular edema. Systemic evaluation was unremarkable except for a 30 mm tuberculin skin test. Relapses occurred after oral and periocular corticosteroids were interrupted, but the inflammation completely disappeared after a 6 month course of isoniazid, rifampicin and pyrazinamide.. Intraocular tuberculosis should be considered as a treatable cause of peripheral multifocal choroiditis, after ruling out other etiologies.

Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antitubercular Agents; Choroiditis; Drug Therapy, Combination; Female; Humans; Isoniazid; Macular Edema; Middle Aged; Pyrazinamide; Radiography; Rifampin; Tuberculin Test; Tuberculosis, Ocular; Tuberculosis, Pulmonary