rifampin and Lupus-Vulgaris

Topics: Aged; Antitubercular Agents; Axilla; Drug Therapy, Combination; Humans; Isoniazid; Lupus Vulgaris; Male; Mycobacterium bovis; Pyrazinamide; Rifampin; Tuberculoma; Tuberculosis, Lymph Node; Ultrasonography

Topics: Adolescent; Antitubercular Agents; Ethambutol; Humans; Isoniazid; Knee; Lupus Vulgaris; Male; Pyrazinamide; Rifampin

Topics: Aged; Antitubercular Agents; Biopsy; Dermatitis; Ethambutol; Female; Humans; Isoniazid; Lupus Vulgaris; Mycobacterium tuberculosis; Nose; Rifampin; Treatment Outcome

Tuberculosis is a common problem in Turkey, and cutaneous tuberculosis is a rare form of extrapulmonary tuberculosis. Herein, the authors describe a case of cutaneous tuberculosis (lupus vulgaris) occurring after contact with a sheep.. A 15-year-old boy was admitted to Marmara University School of Medicine Pendik Training and Research Hospital (Istanbul, Turkey) with delayed wound healing on the left index finger and left axillary lymphadenopathy. His medical history was unremarkable except for a wound incurred when he slaughtered a sheep 3 months before. One month after this injury, the patient developed enlargement of the left axillary lymph node on the side of the wounded extremity, and the wound turned a dark black color. The biopsy specimens obtained from the wounded skin and lymph nodes showed granulomatous reaction, but acid-fast bacilli (AFB) could not be shown with Ehrlich-Ziehl Neelsen staining. The patient tested positive in an interferon-gamma release assay. Computerized tomography scans of the thorax were normal, and early morning gastric lavage specimen was negative for AFB. The wound and axillary lymphadenopathy disappeared after institution of anti-tuberculosis therapy.. Tuberculosis infection must be considered in chronic skin lesions with granulomatous reaction occurring in countries with high prevalence of tuberculosis.

Topics: Abattoirs; Adolescent; Animals; Antitubercular Agents; Axilla; Ethambutol; Finger Injuries; Humans; Isoniazid; Lupus Vulgaris; Lymphadenopathy; Male; Mycobacterium tuberculosis; Occupational Diseases; Pyrazinamide; Rifampin; Sheep; Treatment Outcome; Turkey; Wound Healing

Topics: Adult; Antitubercular Agents; Drug Therapy, Combination; Ethambutol; Female; Humans; Immunocompromised Host; Isoniazid; Kidney Transplantation; Lupus Vulgaris; Pyrazinamide; Rifampin

A small percentage of patients with tuberculosis present with cutaneous findings, which may be difficult to diagnose. We present a patient diagnosed with a rare, non-scarring form of cutaneous tuberculosis (CTB), classically termed as lupus vulgaris erythematoides.

Topics: Adrenal Cortex Hormones; Aged, 80 and over; Anti-Bacterial Agents; Antitubercular Agents; Biopsy; Calcineurin Inhibitors; Dermis; Diagnostic Errors; Drug Therapy, Combination; Eczema; Erythema; Facial Dermatoses; Female; Histiocytosis, Langerhans-Cell; Humans; Immunosuppressive Agents; Isoniazid; Lupus Vulgaris; Mycobacterium tuberculosis; Necrosis; Nose Diseases; Pyrazinamide; Rifampin

Topics: Aged; Antitubercular Agents; Bacteriological Techniques; Chronic Disease; Diagnostic Errors; DNA, Bacterial; Drug Therapy, Combination; Ethambutol; Humans; Isoniazid; Lupus Vulgaris; Male; Mycobacterium tuberculosis; Polymerase Chain Reaction; Predictive Value of Tests; Rifampin; Skin; Time Factors; Treatment Outcome; Tuberculin Test

Topics: Adult; Africa, Northern; Antitubercular Agents; Emigrants and Immigrants; Facial Dermatoses; Female; Humans; Isoniazid; Lupus Vulgaris; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Skin; Spain

Topics: Antitubercular Agents; BCG Vaccine; Carcinoma, Squamous Cell; Child; Ethambutol; Humans; Isoniazid; Lupus Vulgaris; Lymphatic Metastasis; Male; Pyrazinamide; Rifampin; Skin Neoplasms; Treatment Outcome

Lupus vulgaris (LV) is a chronic, progressive, and potentially destructive form of cutaneous tuberculosis commonly seen in previously sensitized individuals with moderate to high immunity. We present a case of LV located on the nose of an 84-year-old female patient, discuss the diagnosis and treatment modalities, and emphasize the importance of having a high index of suspicion for this condition.

Topics: Aged, 80 and over; Antitubercular Agents; Chronic Disease; Ethambutol; Female; Humans; Isoniazid; Lupus Vulgaris; Mycobacterium tuberculosis; Nose Diseases; Pyrazinamide; Rifampin; Skin Ulcer; Treatment Outcome; Tuberculosis, Pulmonary

Tuberculosis is a major public health problem in both developing and developed countries. Cutaneous Tuberculosis constitutes a minor proportion of extra-pulmonary manifestations of Tuberculosis. Lupus Vulgaris (LV) is one of the clinical variants of Cutaneous Tuberculosis. A case of a large plaque type psoriasiform lesion of lupus vulgaris on the thigh, of 15 years' duration, in an 18-year-old girl is reported. This case highlights the ignorance level among the patients and consequent failure to avail proper anti-tuberculous treatment despite campaign in print and audio visual media.

Topics: Adolescent; Antitubercular Agents; Biopsy; Buttocks; Child; Disease Progression; Ethambutol; Female; Humans; Isoniazid; Lupus Vulgaris; Pyrazinamide; Pyridoxine; Rifampin; Tuberculin Test; Vitamin B Complex

Topics: Aged; Aged, 80 and over; Antibiotics, Antitubercular; Antitubercular Agents; Drug Therapy, Combination; Ethambutol; Humans; Isoniazid; Lupus Vulgaris; Male; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Skin; Time Factors; Treatment Outcome; Tuberculin Test

To define the bacteriological and histological correlates of the three predominant clinical forms of cutaneous tuberculosis and to evaluate the efficacy of a 9-month daily regimen containing rifampicin and isoniazid.. In the dermatological clinics of two major teaching hospitals in Chennai, 213 patients with suspected clinical manifestations of cutaneous tuberculosis underwent examination and a skin biopsy for bacteriological and histological tests. They were treated with a daily regimen of rifampicin and isoniazid for 9 months and follow-up for 3 years.. Bacteriological and/or histological confirmation of tuberculosis was obtained in 88% of the cases. Lupus vulgaris lesions were seen mainly in the extremities and verrucosa cutis occurred predominantly on the sole and foot, while the cervical and axillary regions were the commonest sites for scrofuloderma. Ninety-two per cent of the patients showed resolution of the lesions within the first 6 months of chemotherapy; 1% failed to respond to this regimen. There was no relapse in any of the cases during the follow-up period of 3 years.. Clinical findings were adequate to identify major forms of cutaneous tuberculosis as evidenced by bacteriological and histopathological examination. A daily regimen of rifampicin and isoniazid for 9 months was effective in treating cutaneous tuberculosis.

Topics: Adult; Age Distribution; Antibiotics, Antitubercular; Antitubercular Agents; Child; Extremities; Female; Humans; Isoniazid; Lupus Vulgaris; Male; Middle Aged; Rifampin; Sex Distribution; Skin; Treatment Outcome; Tuberculosis, Cutaneous; Tuberculosis, Lymph Node

Pulmonary tuberculosis can be associated with skin manifestations. We report a case in which cutaneous tuberculous lesions were associated with asymptomatic pulmonary tuberculosis. A 15-year old woman had four cutaneous tumoral lesions on her face back, a few of which had evolved over a period of several years. They were asymptomatic nodular lesions, with rounded bumps, with, in places, cheloidal features. The biopsy specimen revealed non-caseating epithelioid granulomas with giant cells and the culture grew Mycobacterium tuberculosis. Cavitating pulmonary tuberculosis was then revealed by CT scan and acid-fast bacilli were isolated in her sputum. The skin lesions disappeared with anti-tuberculosis therapy. Cutaneous manifestations of tuberculosis are rare, polymorphous, and can be associated with an underlying visceral infection. Lupus vulgaris is the most common cutaneous manifestation of tuberculosis in industrialised countries, but nevertheless it remains rare and it is a very unusual presenting feature of underlying pulmonary tuberculosis.

Topics: Adolescent; Antitubercular Agents; Biopsy; Drug Combinations; Female; Humans; Isoniazid; Lupus Vulgaris; Luxembourg; Philippines; Pyrazinamide; Rifampin; Sputum; Tomography, X-Ray Computed; Tuberculosis, Pulmonary

We report two cases of lupus vulgaris one of them on scar of scrofuloderma. We review the treatment of the skin tuberculosis (TBC) and we observed the favorable development to the total regression, using rifampin-isoniazid-pyrizinamide in the first two months and rifampin-isoniazid the four months left to complete six months of global therapy. We discard the monotherapy as treatment for this disease.

Topics: Aged; Antitubercular Agents; Drug Therapy, Combination; Female; Humans; Isoniazid; Lupus Vulgaris; Male; Pyrazinamide; Rifampin

Since 1990 there has been a slight increase in the number of cases of tuberculosis in Norway. Tuberculosis can affect the skin with or without apparent involvement of internal organs. A case of lupus vulgaris in a 13 year-old male Vietnamese refugee is described. The Pirquet test was strongly positive. However, no involvement of lungs or other internal organs was found. Clinical remission was achieved using isoniazide and rifampicin.

Topics: Adolescent; Humans; Isoniazid; Lupus Vulgaris; Male; Norway; Rifampin; Vietnam

It is presented the first case of lupoid syndrome of "BCG-itis" found in El Salvador. Its clinic-pathological study is conclusive for such dermatological entity. The complications of vaccination with BCG are rare. It must be treated as an active tuberculosis, but with a greater control of the patient.

Topics: Adult; BCG Vaccine; Female; Humans; Isoniazid; Lupus Vulgaris; Prednisolone; Pyrazinamide; Rifampin

A patient with a 3 by 4 cm ulcerated lesion on the nose and upper lip in whom previous antibiotics and antifungal treatments for a "mixed infection" were of no avail is presented. Her history revealed that she has had pulmonary and pharyngeal tuberculosis and subsequently scrofuloderma of cervical lymph nodes. She eventually responded well to isoniazid, rifampin, and pyridoxine therapy.

Topics: Antitubercular Agents; Drug Therapy, Combination; Female; Humans; Isoniazid; Lupus Vulgaris; Middle Aged; Pyridoxine; Rifampin

A case of intradermal BCG vaccination was complicated by a lupus-like tuberculosis cutis progressive for over 30 years. The patient had been vaccinated twice with BCG in the affected site. A review of other BCG vaccine-induced cases of lupus vulgaris indicates that the incidence of this complication is markedly increased following multiple BCG vaccinations, but is rare following a single BCG vaccination. In our patient a skin biopsy specimen was characteristic for lupus vulgaris. Acid-fast stains from the tissue and cultures from the affected site were negative. The patient was successfully treated with rifampin.

Topics: Adult; BCG Vaccine; Female; Humans; Lupus Vulgaris; Prednisone; Rifampin

Topics: Adult; Drug Therapy, Combination; Ethambutol; Humans; Lupus Vulgaris; Male; Middle Aged; Rifampin

Topics: Aminosalicylic Acids; Antitubercular Agents; Arthritis; Chemical and Drug Induced Liver Injury; Child; Cycloserine; Drug Hypersensitivity; Drug Resistance, Microbial; Ethambutol; Ethionamide; Humans; Isoniazid; Kanamycin; Liver; Lupus Vulgaris; Male; Middle Aged; Pyrazinamide; Rifampin; Streptomycin; Tuberculin Test; Tuberculosis; Viomycin

Topics: Aminosalicylic Acids; Humans; Isoniazid; Lupus Vulgaris; Male; Middle Aged; Prostatitis; Rifampin; Streptomycin; Tuberculosis, Male Genital

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Female; Humans; Lupus Vulgaris; Male; Middle Aged; Rifampin; Sexually Transmitted Diseases; Skin Diseases; Tuberculosis

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dermatitis, Contact; Eczema; Female; Furunculosis; Humans; Infant; Lupus Vulgaris; Male; Middle Aged; Pyoderma; Rifampin; Skin Diseases; Syphilis, Cutaneous; Tuberculosis, Cutaneous