rifampin and Leukemia

Topics: Animals; Cats; DNA Nucleotidyltransferases; Humans; Kinetics; Leukemia; Mice; Nucleotides; Rifampin; RNA; RNA Viruses; Sarcoma, Experimental

We hypothesize that a large group of medical conditions of unknown etiology including leukemia, multiple myeloma, myelodysplastic and autoimmune disorders, may be associated with or caused by an obscure group of intracellular obligate parasitic bacteria named Ehrlichia/Anaplasma (EA). Ensconced in the stem cells of the bone marrow, EA may disrupt the normal development and function of many of the cells of immunity, manifesting itself as different syndromes. Recent studies of the activity of EA suggest direct effects on the immune system consistent with the manifestations of leukemia. We reference here three leukemia patients with direct or indirect evidence of EA infection. Moreover, EA have been shown to be most sensitive to rifamycins. Two moribund leukemia patients with levels of platelets and white cells incompatible with life were treated with therapeutic doses of Rifampin. Though they did not survive, their condition improved dramatically for a time, suggesting Rifampin provided some therapeutic benefit. We assert that these results warrant more extensive study.

Topics: Adolescent; Anti-Bacterial Agents; Autoimmune Diseases; Blood Platelets; Ehrlichia; Ehrlichiosis; Female; Humans; Immune System; Leukemia; Male; Middle Aged; Multiple Myeloma; Myelodysplastic Syndromes; Polycythemia Vera; Polymerase Chain Reaction; Rifampin

1,3,5-Triazine derivatives were screened for phototoxicity as well as the cytotoxic activities against leukemia and adenocarcinoma derived cell lines in comparison to the normal human keratinocytes. A simple and environmentally friendly procedure has been developed for the synthesis of 1,3,5-triazine derivatives under microwave irradiation in the presence of a HY zeolite. The catalyst can be recovered and reused. Thus, the procedure provides a simple and green synthetic methodology under environmentally friendly conditions. Structure-activity relationships between the chemical structures and antimycobacterial and photosynthesis-inhibiting activity of the evaluated compounds are also discussed.

Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Keratinocytes; Leukemia; Microbial Sensitivity Tests; Models, Chemical; Photosynthesis; Structure-Activity Relationship; Triazines

In this retrospective evaluation of the 4-year clinical use of minocycline and rifampin-impregnated catheters in bone marrow transplantation (BMT) patients, we report low risk of development of staphylococcal resistance to the antibiotics coating the catheters and efficacy in preventing primary staphylococcal bloodstream infections.

Topics: Adult; Anti-Bacterial Agents; Antibiotics, Antitubercular; Bone Marrow Transplantation; Catheterization, Central Venous; Catheters, Indwelling; Cohort Studies; Cross Infection; Drug Delivery Systems; Drug Resistance; Female; Humans; Infection Control; Leukemia; Male; Middle Aged; Minocycline; Neutropenia; Rifampin; Staphylococcal Infections; Texas

Topics: Acute Disease; Amphotericin B; Aspergillosis, Allergic Bronchopulmonary; Drug Administration Schedule; Drug Evaluation; Female; Humans; Leukemia; Middle Aged; Rifampin

Topics: Animals; Cell Membrane; DNA; Friend murine leukemia virus; Genes; Leukemia; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Rifampin; Spleen; Thalassemia; Thymidine

Topics: Antibiotics, Antineoplastic; DNA Nucleotidyltransferases; Humans; Imines; Leukemia; Leukemia, Lymphoid; Lymphocytes; Piperazines; Rauscher Virus; Reverse Transcriptase Inhibitors; Rifampin; Structure-Activity Relationship

Topics: Antibiotics, Antineoplastic; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Cell Differentiation; Cells, Cultured; DNA Nucleotidyltransferases; DNA, Neoplasm; Humans; Hydroxyurea; Kinetics; Leukemia; Leukocytes; Lymphocytes; Mercaptopurine; Methotrexate; Rifampin; RNA, Neoplasm; Thymidine; Tritium; Uridine