rifampin and Leukemia--Myeloid

Two tetrahydroxanthene-1,3(2H)-dione metabolites, valderramenols A (1) and B (2), were isolated from the Philippine endemic Annonaceous species Uvaria valderramensis. Planar structures of the rac-xanthene-1,3-(2H)-diones 1 and 2 were established by MS and NMR measurements. Their enantiomers were separated by chiral HPLC, and the absolute configurations of the separated enantiomers were determined by comparison of the HPLC-ECD spectra with computed TDDFT-generated spectra. A TDDFT-ECD study of the known grandiuvarone (3) allowed the revision of its absolute configuration as S. Compound 1 showed antitubercular activity (MIC 10 μg/mL), while 3 and 4 had weaker activities (MIC 32 μg/mL). Oxepinone 3 exhibited cytotoxic activity against KB-562, a chronic myeloid leukemia cell line.

Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Leukemia, Myeloid; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Philippines; Plant Leaves; Stereoisomerism; Uvaria; Xanthones

Topics: Antibiotics, Antitubercular; Antifungal Agents; Area Under Curve; Communication; Drug Interactions; Humans; Leukemia, Myeloid; Medication Errors; Pyrimidines; Rifampin; Staphylococcal Infections; Triazoles; Voriconazole

Topics: Amphotericin B; Aspergillosis, Allergic Bronchopulmonary; Humans; Leukemia, Myeloid; Male; Middle Aged; Rifampin

We have reported the successful treatment of a patient with acute leukemia complicated by pulmonary aspergillosis, a commonly fatal situation. Specific diagnosis was obtained easily by transbronchial lung biopsy. Our therapeutic approach included aggressive treatment of both the underlying malignant process and the aspergillosis with a combination of amphotericin B and rifampin.

Topics: Amphotericin B; Aspergillosis; Drug Therapy, Combination; Humans; Leukemia, Myeloid; Lung Diseases, Fungal; Male; Middle Aged; Rifampin

Topics: Acute Disease; Adult; Animals; Cattle; Chromatography, Ion Exchange; Deoxyribonucleotides; DNA Nucleotidyltransferases; Ethylmaleimide; Humans; Hydrogen-Ion Concentration; Kinetics; Leukemia, Myeloid; Leukocytes; Magnesium; Male; Manganese; Molecular Weight; Oligonucleotides; Polynucleotides; Rifampin; Structure-Activity Relationship; Thymus Gland; Tritium; Ultracentrifugation