rifampin and Leukemia--Hairy-Cell

Legionella pneumonia is frequently reported in immunocompromised patients. The most important predisposing factor is a quantitative and qualitative defect of the monocytic-macrophagic system. We report a case of Legionella pneumophila in a 43-year-old man revealing hairy cell leukemia. The patient presented with community-acquired pneumonia resistant to common antibiotics. Serology provided the diagnosis and the patient improved with adequate treatment. Early diagnosis and appropriate treatment may reduce the mortality of this serious complication.

Topics: Adult; Antibiotics, Antitubercular; Humans; Legionella pneumophila; Legionnaires' Disease; Leukemia, Hairy Cell; Male; Rifampin

A 36-year-old man with treated hairy cell leukemia developed a skin infection due to Mycobacterium marinum. A spectrum of atypical cutaneous mycobacteriosis presentations with immunosuppression can be found. The recognition of the disease needs cutaneous biopsies for histopathology and its identification by specific laboratory methods to adapt treatment.

Topics: Adult; Biopsy; Clarithromycin; Drug Therapy, Combination; Granuloma; Humans; Leukemia, Hairy Cell; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Rifampin; Skin Diseases, Bacterial

We describe a patient with hairy cell leukemia and protracted fever. The patient's condition deteriorated during treatment with alfa Interferon 2b, and his fever persisted. A slight widening of the upper mediastinum appeared after 2.5 months. Mediastinoscopy with lymph node biopsy revealed granulomatous infiltrates with acid-fast bacilli. Cultures of the lymph node material later showed growth of Mycobacterium malmoense. The patient was treated with rifampicin, doxycycline, etambutol and cycloserin for sixteen months and remains afebrile and is gaining weight. His general condition is still improving. An aggressive diagnostic approach is necessary in febrile patients with hairy cell leukemia.

Topics: Adult; Bone Marrow; Cycloserine; Doxycycline; Ethambutol; Humans; Leukemia, Hairy Cell; Male; Mycobacterium Infections; Rifampin