rifampin and Leg-Dermatoses

Topics: Biopsy; Chronic Disease; Clarithromycin; Dermis; Diagnosis, Differential; Doxycycline; Drug Therapy, Combination; Epidermis; Female; Humans; Immunocompetence; Leg Dermatoses; Lymphedema; Middle Aged; Mycobacterium Infections, Nontuberculous; Rifampin

Topics: Adult; Clofazimine; Drug Therapy, Combination; Humans; Leg Dermatoses; Leprostatic Agents; Leprosy, Lepromatous; Male; Rifampin; Torso; Treatment Outcome

Verrucous leprosy is rare, with only 18 cases reported in the literature. Visceral involvement is frequent but often overlooked, causing significant morbidity and mortality.. A 45-year-old Filipino male with a 16-year history of hyperpigmented, hypoesthetic plaques, amputated digits, enlarged ulnar nerve, and cardiovascular congestion was diagnosed with Hansen's disease-lepromatous type. He had multiple cauliflower-like nodules and plaques with foul-smelling discharge on the lower extremities presenting a diagnostic dilemma. After an exhaustive search, the causative agent for these verrucous nodules was confirmed to still be Mycobacterium leprae. In addition, he had glomerulonephritis, hypertension, congestive heart failure, deep venous thrombosis, neuritis, keratitis, and glaucoma, which are all complications of advanced leprosy and multiple attacks of erythema nodosum leprosum reactions.. He was treated with a multibacillary regimen of Rifampicin, Dapsone, Clofazimine, and systemic corticosteroids, with remarkable improvement.

Topics: Biopsy; Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Glucocorticoids; Humans; Leg Dermatoses; Leprostatic Agents; Leprosy, Lepromatous; Male; Middle Aged; Philippines; Prednisone; Rifampin

Leprosy is now considered in Western Europe as a strictly imported disease. A case of presumed locally acquired diffuse lepromatous leprosy was observed in a native-Portuguese woman living in France who developed an acute febrile presentation with extensive cutaneous signs.

Topics: Biopsy, Needle; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Facial Dermatoses; Female; Fever; Follow-Up Studies; France; Humans; Immunohistochemistry; Leg Dermatoses; Leprosy, Lepromatous; Middle Aged; Rifampin; Risk Assessment; Severity of Illness Index; Treatment Outcome

We report three adult cases of very chronic, extensive infection of the lower limbs due to Mycobacterium marinum. The patients were from South Pacific islands and, clinically, the widespread warty plaques resembled chromomycosis. One was associated with severe lymphoedema. All three patients gave a history of at least 20 years duration. The patients were otherwise well and not immunologically compromised. In all cases, the organism was identified on tissue cultures and was not seen on histopathology. The mycobacteria were sensitive to most antibiotics tested in vitro. The patients were treated with a combination of rifampicin and cotrimoxazole with good results.

Topics: Adult; Aged; Anti-Bacterial Agents; Antibiotics, Antitubercular; Chromoblastomycosis; Chronic Disease; Culture Techniques; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Leg Dermatoses; Lymphedema; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Pacific Islands; Rifampin; Time Factors; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination

This study reports the clinical profile and therapeutic response of seventy-two mono-lesions leprosy cases. These 72 cases were among 578 paucibacillary (PB) cases classified according to WHO (1982) and were followed-up on multidrug therapy (MDT). Of these 72 mono-lesion cases, 46 (64%) were tuberculoid (TT) cases, 24 (33%) were Indeterminate (Ind) cases and 2 (3%) were of borderline tuberculoid (BT) types. While 37.5% of these cases presented as macular patches, the remaining 62.5% had raised erythematous lesions. In majority of cases (94%), the lesions were present on the exposed parts like legs and feet, arms and hands, face, whereas only 6% presented on covered areas of trunk and buttocks. These cases were treated with dapsone 100 mg daily for 12 months and rifampicin 600 mg once a month for 6 months. After 6 months of MDT, lesions in 81% of the patients regressed clinically and by one year of therapy 96% of cases had regressed. Treatment was stopped in all cases by one year of therapy. There were no relapse or late reaction in the 5 years of post treatment follow-up. The response of mono-lesion PB cases was better than the multi-lesions PB cases at 6 months and during the post treatment follow-up period.

Topics: Adolescent; Adult; Arm; Dapsone; Drug Therapy, Combination; Facial Dermatoses; Follow-Up Studies; Humans; Leg Dermatoses; Leprosy, Borderline; Leprosy, Tuberculoid; Middle Aged; Recurrence; Remission Induction; Rifampin

Topics: DNA, Bacterial; Erythema Induratum; Ethambutol; Female; Humans; Isoniazid; Leg Dermatoses; Middle Aged; Mycobacterium tuberculosis; Polymerase Chain Reaction; Rifampin

Topics: Adult; Drug Therapy, Combination; Ethambutol; Female; Humans; Leg Dermatoses; Mycobacterium Infections; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Rifampin

Topics: Adult; Female; Humans; Isoniazid; Kidney Transplantation; Leg Dermatoses; Mycobacterium Infections; Rifampin; Skin Diseases, Infectious