rifampin and Laryngeal-Diseases

Myobacterium malmoense is a non-tuberculous mycobacterium that most commonly causes pulmonary infection, particularly in patients with underlying pulmonary disease or immunodeficiency. We describe a case of Mycobacterium malmoense infection of the larynx in a previously well middle-aged woman, which has previously not been reported. The case highlights the importance of considering atypical mycobacterial infection in the differential diagnosis of laryngeal lesions.

Topics: Aged; Clarithromycin; Drug Therapy, Combination; Ethambutol; Female; Hoarseness; Humans; Isoniazid; Laryngeal Diseases; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Pyridoxine; Rifampin; Sputum; Staining and Labeling

In the preantibiotic era laryngeal tuberculosis was the most frequent pathology of the larynx. In the last decades some changes in the presentation and evolution of the pathology have occurred due to the new chemiotherapy and the improvement of the nutrition. Actually it presents less incidence and infectivity and less evidence of pulmonary disease. In this article we analyse, on occasion of a clinical case and with a revision of the literature, the actual patterns of the laryngeal tuberculosis.

Topics: Aged; Antitubercular Agents; Drug Therapy, Combination; Female; Humans; Isoniazid; Laryngeal Diseases; Mycobacterium tuberculosis; Rifampin; Tomography, X-Ray Computed; Tuberculosis

Sarcoidosis is a multisystem disease of unknown etiology characterized by non-caseating granulomatous inflammation of various organs, but most frequently involving the lungs of young adults. Sarcoidosis is rare in the pediatric age group, however numerous extensive reviews have been published. The most commonly seen initial manifestations in childhood are non-specific constitutional symptoms such as lethargy, fatigue and malaise, followed by cough, dyspnea, fever, weight loss, and lymphadenopathy in order of decreasing frequency. The diagnosis is one of exclusion and is established when clinical and radiological findings are supported by histological evidence of widespread non-caseating epithelial cell granulomas in more than one organ, or a positive Kveim test. Laryngeal involvement is usually part of the systemic disease, but isolated laryngeal sarcoidosis has been reported in adults. We report here a case of isolated laryngeal sarcoidosis in a 13 year old girl. The differential diagnosis and management are discussed.

Topics: Adolescent; Diagnosis, Differential; Epiglottis; Female; Humans; Isoniazid; Laryngeal Diseases; Laryngeal Mucosa; Prednisone; Rifampin; Sarcoidosis; Tuberculosis

Topics: Aged; Dapsone; Humans; Laryngeal Diseases; Leprosy; Male; Rifampin