rifampin and Lacrimal-Apparatus-Diseases

To report a rare case of nasolacrimal tuberculosis, conduct a literature review, and to suggest an optimal management plan.. A 39-year old Zimbabwean female presented with a 3-year history of left epiphora, haemolacria and medial canthal mass. On ophthalmic examination there was no lateral displacement of the left globe. The initial management was external dacryocystorhinostomy. Histology of the biopsy was inconclusive and her symptoms did not improve. This prompted a referral to otolaryngology. Nasal examination revealed a friable mass of the middle turbinate. CT scan showed paranasal sinus and lacrimal sac destruction and lateral displacement of the globe. Endoscopic sinus surgery confirmed the CT findings, allowed a biopsy taken, and the histology showed prominent caseating granulomatous inflammation. Microbiological cultures confirmed nasolacrimal tuberculosis.. We report a case of primary tuberculosis affecting the nasolacrimal apparatus presenting with a medial canthal mass. This report highlights the need for high index of suspicion, and initial CT imaging in order to avoid invasive procedures such as external dacryocystorhinostomy, which may cause extra surgical morbidity and delay diagnosis and treatment.

Topics: Adult; Antitubercular Agents; Drug Combinations; Drug Therapy, Combination; Endoscopy; Ethambutol; Female; Humans; Isoniazid; Lacrimal Apparatus Diseases; Nasolacrimal Duct; Pyrazinamide; Pyridoxine; Rifampin; Tomography, X-Ray Computed; Tuberculosis, Ocular