rifampin and Kidney-Tubular-Necrosis--Acute

Topics: Allopurinol; Aminoglycosides; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents; Captopril; Cephalosporins; Cisplatin; Diuretics; Glomerulonephritis; Gold; Humans; Kidney; Kidney Diseases; Kidney Tubular Necrosis, Acute; Lithium; Nephritis, Interstitial; Penicillamine; Penicillins; Rifampin; Semustine; Sulfonamides; Tetracycline; Trimethadione

Drug-induced kidney injury, a major cause of acute kidney injury, results in progressive kidney disease and is linked to increased mortality in hospitalized patients. Primary injury sites of drug-induced kidney injury are proximal tubules. Clinically, kidney injury molecule-1, an established tubule-specific biomarker, is monitored to assess the presence and progression of injury. The ability to accurately predict drug-related nephrotoxicity preclinically would reduce patient burden and drug attrition rates, yet state-of-the-art in vitro and animal models fail to do so. In this study, we demonstrate the use of kidney injury molecule-1 measurement in the kidney microphysiological system as a preclinical model for drug toxicity assessment. To show clinical relevance, we use quantitative systems pharmacology computational models for in vitro-in vivo translation of the experimental results and to identify favorable dosing regimens for one of the tested drugs.

Topics: Biomarkers; Cell Line; Cisplatin; Gentamicins; Hepatitis A Virus Cellular Receptor 1; Humans; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proximal; Models, Theoretical; Rifampin; Translational Research, Biomedical

Endosulphan is a chlorinated hydrocarbon insecticide with potential toxicity for the respiratory and central nervous systems. Renal toxicity has been rarely reported. We describe a man who developed renal failure due to acute tubular necrosis following a suicidal attempt with endosulphan in the absence of significant hypotension or sepsis.

Topics: Aged; Anti-Bacterial Agents; Endosulfan; Fatal Outcome; Humans; Isoniazid; Kidney Tubular Necrosis, Acute; Male; Rifampin; Suicide, Attempted; Tuberculosis, Pulmonary

Topics: Acute Kidney Injury; Adult; Female; Humans; Kidney; Kidney Tubular Necrosis, Acute; Male; Middle Aged; Respiratory Tract Infections; Rifampin; Tuberculosis, Pulmonary

Topics: Acute Kidney Injury; Adult; Female; Humans; Kidney Tubular Necrosis, Acute; Middle Aged; Rifampin; Time Factors; Tuberculosis