rifampin and Influenza--Human

Topics: Acute Kidney Injury; Anemia, Hemolytic; Digestive System; Humans; Influenza, Human; Liver; Rifampin; Skin; Syndrome; Thrombocytopenia; Tuberculosis, Pulmonary

Topics: Amantadine; Anti-Inflammatory Agents; Antimetabolites; Antiviral Agents; Chemical Phenomena; Chemistry; Herpesviridae Infections; Humans; Idoxuridine; Immunosuppression Therapy; Influenza, Human; Interferons; Isoquinolines; Oxolinic Acid; Respiratory Tract Infections; Rifampin; Smallpox; Thiosemicarbazones; Virus Diseases

Topics: Acrylates; Amantadine; Amidines; Amino Acids; Animals; Anti-Bacterial Agents; Antiviral Agents; Benzimidazoles; Chemical Phenomena; Chemistry; Culture Techniques; Cytarabine; Daunorubicin; Guanidines; Herpesviridae Infections; Heterocyclic Compounds; Humans; Idoxuridine; Influenza, Human; Interferons; Isoquinolines; Peptides; Polynucleotides; Rifampin; RNA; Thiosemicarbazones; Triazines

Topics: Amantadine; Animals; Antiviral Agents; Benzimidazoles; Culture Techniques; Cytarabine; DNA Nucleotidyltransferases; DNA Replication; Herpesviridae Infections; Humans; Idoxuridine; Infant; Influenza, Human; Interferons; Mice; Phenanthridines; Poliomyelitis; Protein Binding; Rabbits; Rifampin; RNA, Viral; Smallpox; Templates, Genetic; Thiosemicarbazones; Viral Proteins; Virus Diseases; Virus Replication

Topics: Amantadine; Anti-Bacterial Agents; Antiviral Agents; Binding Sites; Gastroenteritis; Herpesviridae Infections; Humans; Idoxuridine; Influenza, Human; Interferons; Poxviridae Infections; Respiratory Tract Infections; Rifampin; Steroids; Thiosemicarbazones; Virus Diseases; Virus Replication

Purulent pericarditis occurs rarely in the current antibiotic era. We describe clinical and echocardiographic features of purulent pericarditis in a previously healthy child with influenza and community-acquired methicillin-resistant Staphylococcus aureus co-infection. The child was already on appropriate antibiotics and had a very subtle clinical presentation, with prominent abdominal symptoms. Timely surgical drainage led to complete recovery.

Topics: Anti-Bacterial Agents; Child, Preschool; Community-Acquired Infections; Humans; Influenza B virus; Influenza, Human; Male; Methicillin-Resistant Staphylococcus aureus; Pericarditis; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Vancomycin

Topics: Adult; Bacterial Vaccines; Child; Child, Preschool; Haemophilus Infections; Humans; Immunization Schedule; Infant; Influenza, Human; Rifampin; Vaccination

We describe a woman with the 'flu' like syndrome and haemolysis whilst on a supervised daily rifampicin regimen for the treatment of pulmonary tuberculosis. Although these are known complications of rifampicin therapy, they often occur when therapy is intermittent or interrupted. Hence the case we describe is unique and is the first of its kind to be reported in Singapore.

Topics: Adult; Anemia, Hemolytic; Diagnosis, Differential; Female; Hemolysis; Humans; Influenza, Human; Rifampin; Time Factors; Tuberculosis, Pulmonary

Topics: Humans; Influenza, Human; Male; Middle Aged; Rifampin; Syndrome; Tuberculosis, Osteoarticular

An epidemic of meningococcal disease after an influenza outbreak in a community of 49 boys (14-18 years) and 8 adults in a boarding-school is reported. The first patient died with all symptoms of the Waterhouse-Friderichsen syndrome. Several hours later, two other boys developed severe septicemia with meningitis and meningitis respectively. N. meningitidis group B susceptible to penicillin and rifampin was isolated. Within the next 8 hours, chemoprophylaxis with rifampin (600 mg twice daily) was started and maintained for 4 days for the whole community. Throat cultures had not been obtained before prophylaxis. Ten other symptomatic boys were admitted to the hospital and treated by penicillin infusion. The results of blood and cerebrospinal fluid cultures were negative, and treatment was therefore discontinued. Five days after the death of the first boy, another boy died with full-blown Waterhouse-Friderichsen syndrome while on chemoprophylaxis. The neisseriae isolated from this patient were rifampin-resistant. Serological investigations in all patients admitted to hospital revealed the existence of concomitant epidemic infection with influenza A and B in this school. We assume that the viral infection made way for the outbreak of the meningococcal disease and for the high rate of secondary meningococcal infection. Chemoprophylaxis with rifampin should not be continued for longer than 2 to 3 days, otherwise the risk of occurrence of rifampin resistant strains of N. meningitidis increases. Hitherto such strains have rarely been isolated in clinically manifest disease.

Topics: Adolescent; Adult; Disease Outbreaks; Humans; Influenza, Human; Male; Meningitis, Meningococcal; Meningococcal Infections; Neisseria meningitidis; Penicillin Resistance; Penicillins; Rifampin; Schools; Switzerland; Waterhouse-Friderichsen Syndrome

Topics: Amantadine; Animals; Antiviral Agents; Cytarabine; Encephalitis; Herpes Labialis; Herpes Simplex; Herpesvirus 3, Human; Humans; Idoxuridine; Indoles; Influenza, Human; Interferons; Keratitis, Dendritic; Rifampin; Thiosemicarbazones; Vaccinia