rifampin and Inappropriate-ADH-Syndrome

A forty-nine-year-old female patient with pulmonary tuberculosis developed syndrome of inadequate antidiuretic hormone secretion. Consequent restriction of fluid intake as a therapeutic measure was just as ineffective as a medication with tolvaptan which was performed later on. A probable explanation for the inefficacy of the aquaretic drug is an interaction of rifampicine and tolvaptan. This case report gives a short summary of SIADH in pulmonary TB and discusses possible reasons for the difficult antituberculotic treatment in this patient.

Topics: Antibiotics, Antitubercular; Benzazepines; Combined Modality Therapy; Diet, Sodium-Restricted; Drug Interactions; Female; Fluid Therapy; Humans; Inappropriate ADH Syndrome; Middle Aged; Rifampin; Syndrome; Tolvaptan; Treatment Failure; Tuberculosis, Pulmonary