rifampin and Ileal-Diseases

A 44-year-old man consulted medical clinic, complaining of cough and sputum. Then he was admitted to our hospital, because of positive acid-fast bacilli in his sputum and positive PCR (polymerase chain reaction) for Mycobacterium tuberculosis. Combined use of isoniazid (INH), rifampicin (RFP), ethambutol (EB) and pyrazinamide (PZA) was started. But 4 days after starting treatment, we had to suspend tuberculosis chemotherapy because of hepatopathy. Since then he started to complain epigastralgia and vomiting. Plain abdominal X-ray and abdominal computed tomography (CT) led to a diagnosis of ileus. Inspite of insertion of ileus tube symptoms of ileus did not improve. Small bowl series showed severe stenosis at ileum end, necessitating jejunectomy. Macroscopic study revealed a ring ulcer and multiple epithelioid cell granuloma with Langhans' giant cells was detected histopathologically. PCR for M. tuberculosis of extracts from ileum was positive. Therefore the patient was diagnosed small intestinal tuberculosis. Treatment was continued by the combination of INH, RFP, EB, and the symptoms markedly improved. There have been no sign of recurrence since the end of the 6-month treatment for tuberculosis.

Topics: Adult; Antitubercular Agents; Ethambutol; Humans; Ileal Diseases; Ileus; Isoniazid; Male; Pyrazinamide; Rifampin; Tuberculosis, Gastrointestinal; Tuberculosis, Pulmonary

A case of jejuno-ileal tuberculosis in a patient thought to be suffering from Crohn's disease is described, with special reference to the use of intravenous rifampicin in the postoperative phase.

Topics: Adult; Humans; Ileal Diseases; Infusions, Parenteral; Jejunal Diseases; Male; Postoperative Care; Rifampin; Time Factors; Tuberculosis, Gastrointestinal