rifampin and Hemorrhagic-Disorders

Topics: Aminosalicylic Acids; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cycloserine; Drug Resistance, Microbial; Drug Synergism; Drug Tolerance; Hemorrhagic Disorders; Humans; Isoniazid; Kanamycin; Phenylthiourea; Purpura, Thrombocytopenic; Pyrazines; Recurrence; Rifampin; Streptomycin; Tuberculosis, Pulmonary

We aimed to examine cases of brucellosis that presented with severe thrombocytopenia and hemorrhagic diathesis.. A total of 10 brucellosis cases with severe thrombocytopenia were included in this case-series study. Patients' files were reviewed for their clinical and laboratory findings, as well as clinical outcomes and complications. Platelet counts of < 20,000/mm³ were diagnosed as severe thrombocytopenia.. The lowest thrombocyte count was 3000/mm³ while the highest was 19,000/mm³ (mean: 12,000/mm³). Patients had the following symptoms: epistaxis (7 cases), petechia with epistaxis (4 cases), bleeding gums (3 cases), ecchymosis with epistaxis (2 cases), melena and renal failure (2 cases), and hematuria (1 case). Patients were given rifampicin and doxycycline along with supportive hematological therapy. All were treated successfully with no evidence of recurrence at follow-up visits.. Since brucellosis is endemic in developing countries, it must be considered in the differential diagnosis of cases that present with severe thrombocytopenia and hemorrhagic diathesis.

Topics: Brucellosis; Hemorrhagic Disorders; Humans; Platelet Count; Rifampin; Thrombocytopenia

Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Female; Fetal Death; Hemorrhagic Disorders; Humans; Infant; Infant, Newborn; Pregnancy; Rabbits; Rats; Rifampin; Teratogens

Topics: Acute Kidney Injury; Antibodies; Dose-Response Relationship, Drug; Drug Hypersensitivity; Hemorrhagic Disorders; Humans; Respiratory Insufficiency; Rifampin; Tuberculosis, Pulmonary