rifampin has been researched along with Hematoma* in 3 studies
3 other study(ies) available for rifampin and Hematoma
Article | Year |
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Antibacterial Envelope Is Associated With Low Infection Rates After Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Device Replacement: Results of the Citadel and Centurion Studies.
This study sought to determine whether the nonabsorbable TYRX Antibacterial Envelope (TYRX) reduces major cardiovascular implantable electronic device (CIED) infections 12 months after implant.. TYRX is a monofilament polypropylene mesh impregnated with minocycline and rifampin specifically designed to hold a CIED in place and elute antimicrobials over time. There are limited data on its ability to reduce CIED infections.. We prospectively enrolled patients who underwent generator replacement with an implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy device (CRT), treated with TYRX. The primary endpoints were major CIED infection and CIED mechanical complications. Given the differences in infection rates among ICD and CRT patients, 3 different control populations were used: a published benchmark rate for ICD patients, and both site-matched and comorbidity-matched controls groups for CRT patients.. Overall, a major CIED infection occurred in 5 of 1,129 patients treated with TYRX (0.4%; 95% confidence interval: 0.0% to 0.9%), significantly lower than the 12-month benchmark rate of 2.2% (p = 0.0023). Among the TYRX-treated CRT cohort, the major CIED infection rate was 0.7% compared with an infection rate of 1.0% and 1.3% (p = 0.38 and p = 0.02) in site-matched and comorbidity-matched control groups, respectively. Among the ICD group, the 12-month infection rate was 0.2% compared with the published benchmark of 2.2% (p = 0.0052). The most common CIED mechanical complication in study patients was pocket hematoma, which occurred in 18 of the 1,129 patients (1.6%; 95% confidence interval: 0.8 to 2.5), which is comparable with a published rate of 1.6%.. Use of TYRX was associated with a lower major CIED infection rate. (TYRX™ Envelope for Prevention of Infection Following Replacement With a CRT or ICD; [Centurion]; NCT01043861/NCT01043705). Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Cardiac Resynchronization Therapy; Defibrillators, Implantable; Delayed-Action Preparations; Female; Follow-Up Studies; Hematoma; Humans; Male; Middle Aged; Minocycline; Prospective Studies; Prosthesis-Related Infections; Reoperation; Rifampin; Risk Factors; Surgical Mesh | 2017 |
Impact of drug interactions when medications are stopped: the often forgotten risks.
Topics: Aged, 80 and over; Anemia; Antibiotics, Antitubercular; Anticoagulants; Drug Interactions; Hematoma; Humans; Male; Muscular Diseases; Polypharmacy; Rifampin; Risk; Warfarin | 2014 |
Massive spontaneous perirenal hematoma and accelerated hypertension in a patient with polyarteritis nodosa.
A 43-year-old Albanian man is presented who underwent nephrectomy for a huge right spontaneous perirenal hematoma. The diagnosis of polyarteritis nodosa as the etiology of the hematoma has been made only by histological examination, because of the quick and unforeseeable onset of this complication and the nonspecificity of symptoms. We hypothesize a relationship between reactivation of polyarteritis nodosa and treatment with rifampicin and isoniazid. Topics: Adult; Antitubercular Agents; Hematoma; Humans; Hypertension, Renal; Isoniazid; Kidney; Kidney Diseases; Male; Mycobacterium Infections, Nontuberculous; Nephrectomy; Polyarteritis Nodosa; Rifampin | 2003 |