rifampin and Hand-Dermatoses

Mycobacterium marinum is a nontuberculous mycobacteria that is often acquired via contact with contaminated salt or fresh water. We present a case of a 67-year-old man who developed several solitary nontender nodules on his hands and forearm after working on the underside of his boat. In addition, we provide a review of the literature and discuss how this infection is acquired, the underlying pathogenesis, the cutaneous and histologic findings, the differential diagnosis, the diagnostic methods, and the various treatment options.

Topics: Aged; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antitubercular Agents; Clarithromycin; Ethambutol; Forearm; Hand Dermatoses; Humans; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Rifampin; Skin Diseases, Bacterial

A sporotrichoid pattern describes a clinical presentation in which inflammatory nodules spread along the path of lymphatic drainage, being reported in association with several infectious, neoplastic, and inflammatory skin conditions. Herein, we report a 65-year-old man presenting with a three-month history of erythematous nodules in a linear distribution along the left hand and forearm. He reported recent rose gardening and regular contact with an aquarium. The diagnosis was made through culture of skin biopsy tissue and isolation of Mycobacterium marinum. The patient was treated with a combination of clarithromycin and rifampicin and clinical resolution was evident within two months. We present a patient with a sporotrichoid cutaneous infection by Mycobacterium marinum, highlighting that even with the availability of novel microbiological detection techniques, tissue culture remains an essential tool for diagnostic confirmation.

Topics: Aged; Anti-Bacterial Agents; Biopsy; Clarithromycin; Culture Techniques; Forearm; Hand Dermatoses; Humans; Male; Mycobacterium Infections, Nontuberculous; Rifampin; Skin Diseases, Bacterial

Topics: Adult; Dapsone; Drug Therapy, Combination; Female; Hand; Hand Dermatoses; Humans; Hyperpigmentation; Hypesthesia; Leprostatic Agents; Leprosy, Tuberculoid; Rifampin

Topics: Brazil; Dapsone; Delayed Diagnosis; Facial Dermatoses; Female; Foot Dermatoses; Hand Dermatoses; Humans; Hypesthesia; Immunity, Cellular; Leprosy, Tuberculoid; Occupational Exposure; Prednisone; Pregnancy; Pregnancy Complications, Infectious; Rifampin; Spain

A 43-year-old man visiting Texas from Hawaii sought care at our dermatology clinic for nonpruritic erythematous plaques on his chest, back, and extremities. The patient reported occasional numbness in his fingers and feet, but denied constitutional symptoms. The patient, who'd had these symptoms for a year, had been previously diagnosed with chronic urticaria and treated with oral antihistamines. He reported that the lesions were never particularly pruritic and he had not responded to previous treatments. An avid outdoorsman, our patient was born and raised in Texas and had been living in Hawaii. His past medical history was significant for severe hand eczema and when asked about medications he was taking, he listed cetirizine, doxepin, and hydroxyzine. On physical examination the patient had multiple pink to red, nonscaly to minimally scaly flat plaques on his forehead, chest, proximal upper extremities, lower back, and distal lower extremities. A 4-mm punch biopsy was taken from a lesion on his lower back and sent for histologic evaluation. The patient's erythrocyte sedimentation rate, rapid plasma reagin, and complete blood count were all within normal limits. What is your diagnosis? How would you treat this patient?

Topics: Adult; Animals; Armadillos; Biopsy; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Erythema; Hand Dermatoses; Humans; Leprostatic Agents; Leprosy, Multibacillary; Male; Rifampin; Skin; Zoonoses

Topics: Animals; Animals, Domestic; Anti-Bacterial Agents; Antibiotics, Antitubercular; Diabetes Mellitus, Type 2; Drug Resistance, Bacterial; Fishes; Hand Dermatoses; Humans; Male; Middle Aged; Minocycline; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Rifampin; Risk Factors; Skin Diseases, Bacterial; Spinocerebellar Degenerations; Water Microbiology

An unusual case of multiple lesions of tuberculosis verrucosa cutis and colliquative forms is reported. We emphasize a rapid response to conventional therapy.

Topics: Adult; Antibiotics, Antitubercular; Antitubercular Agents; Drug Therapy, Combination; Ethambutol; Female; Foot Dermatoses; Hand Dermatoses; Humans; Isoniazid; Pyrazinamide; Rifampin; Tuberculosis, Cutaneous

We report two pediatric patients with recalcitrant staphylococcal infections whose infections resolved when rifampin was added to standard antistaphylococcal therapy. One patient had a post-varicella staphylococcal ulcerative lesion and did not respond to cephalexin alone but did respond when rifampin was added. A second patient had staphylococcal bullous impetigo and did not respond to dicloxacillin or cephalexin but did respond when rifampin was added to the cephalexin. If a patient fails to respond to traditional antistaphylococcal therapy, the addition of rifampin may be beneficial.

Topics: Cephalexin; Chickenpox; Child; Drug Therapy, Combination; Hand Dermatoses; Humans; Impetigo; Male; Prospective Studies; Rifampin; Skin Diseases, Infectious; Skin Diseases, Vesiculobullous; Staphylococcal Infections; Wound Infection

Topics: Diabetes Complications; Drug Therapy, Combination; Ethambutol; Female; Hand Dermatoses; Humans; Middle Aged; Mycobacterium Infections; Rifampin; Skin Diseases, Infectious

Topics: Debridement; Ethambutol; Female; Hand Dermatoses; Hand Injuries; Humans; Inflammation; Male; Middle Aged; Mycobacterium; Mycobacterium Infections; Radiography; Rifampin; Synovectomy; Water Microbiology