rifampin and Glycosuria

Intermittent rifampicin therapy has been reported to commonly cause a flu-like illness with chills and fever sometimes associated with acute renal failure. This report describes a fourth case of partially reversible insidious renal damage associated with continuous rifampicin therapy and provides evidence that it is not the results of light chain proteinuria as previously suggested. A retrospective review of data relating to renal function in 89 tuberculous patients indicated that increased plasma urate concentration was commonly associated with ethambutol therapy.

Topics: Acute Kidney Injury; Bicarbonates; Creatinine; Ethambutol; Female; Glycosuria; Humans; Hypokalemia; Male; Middle Aged; Retrospective Studies; Rifampin; Tuberculosis, Pulmonary

In a patient with tuberculosis and acute renal failure related to administration of therapeutic rifampin, treatment was discontinued for five weeks. It was reinstituted three weeks later. Unlike other patients previously described, the expected adverse renal reaction occurred only gradually and without symptoms, although tubular and glomerular disease developed. Also unique was a striking deposition of immunoglobulin about the tubules. This finding, in association with interstitial nephritis and tubular glycosuria, is similar to an experimental autologous renal disease mediated by antibody to tubular basement membrane.

Topics: Acute Kidney Injury; Autoantibodies; Basement Membrane; Complement C3; Creatinine; Fibrinogen; Glomerulonephritis; Glycosuria; Humans; Immunoglobulin A; Immunoglobulin G; Kidney Tubules; Male; Methods; Middle Aged; Nephritis, Interstitial; Rifampin; Time Factors; Tuberculosis, Pulmonary