rifampin and Glossitis

A 3-year-old, intact female mixed-breed dog, weighing 7 kg, was presented with generalised swelling of the tongue, leading to impaired deglutition and episodes of dyspnoea. From the age of 2 years, the dog had been under immunosuppressive therapy due to atopic dermatitis.. Multiple nodular lesions at the apex of the tongue were noted as well as mandibular and retropharyngeal lymph node enlargement. Serum biochemistry results showed inflammatory changes. The results of several biopsies taken over 7 months indicated persistent pyogranulomatous and necrotising glossitis despite ongoing antimicrobial treatment, first with amoxicillin/clavulanic acid and then pradofloxacin. No foreign material, acid-fast bacteria or fungal hyphae were detected throughout. The final diagnosis of. Severe chronic pyogranulomatous and necrotising glossitis associated with infection by. This report describes challenges in the diagnosis and therapy of a localised. AF: Acid-fast; ALP: Alkaline phosphatase; CT: Computed tomography; MAC:

Topics: Alkaline Phosphatase; Amoxicillin; Animals; Anti-Bacterial Agents; Clarithromycin; Clavulanic Acid; Dog Diseases; Dogs; Doxycycline; Female; Glossitis; Immunomodulation; Mycobacterium; Mycobacterium avium; Rifampin