rifampin and Glomerulosclerosis--Focal-Segmental

The incidence of tuberculosis (TBC) in patients undergoing maintenance hemodialysis is reported to be higher than that in the general population. We report an 8-year-old boy receiving such treatment for chronic renal failure who developed mediastinal lymph node TBC. He showed only intermittent fever, recurring every 2 weeks, with no other symptoms suggesting TBC. Although staining and culture of pharyngeal swab and gastric juice specimens failed to provide evidence of TBC, a lymph node biopsy specimen disclosed typical pathologic findings of tuberculoma, including caseating granulomas. Antituberculous therapy with isoniazid (INH), rifampicin, pyrazinamide, and ethambutol was given for 12 months, resulting in complete resolution of the TBC, with no subsequent recurrence. To our knowledge, mediastinal lymph node localization of TBC is relatively rare, in a patient on maintenance hemodialysis, especially in a child.

Topics: Child; Drug Therapy, Combination; Glomerulosclerosis, Focal Segmental; Humans; Isoniazid; Lymph Nodes; Male; Mediastinum; Mycobacterium tuberculosis; Pyrazinamide; Renal Dialysis; Rifampin; Tuberculosis, Lymph Node

We report a patient who developed progressive renal failure following 13 months of rifampicin therapy for renal tuberculosis. The renal function continued to deteriorate despite the discontinuation of rifampicin. Renal pathology did not demonstrate any evidence of tuberculosis of the kidney but revealed the unique pathological finding of glomerulosclerosis, granulomatous interstitial nephritis, and extensive papillary necrosis.

Topics: Adult; Female; Glomerulosclerosis, Focal Segmental; Humans; Kidney Papillary Necrosis; Nephritis, Interstitial; Rifampin; Tuberculosis, Renal; Uremia