rifampin and Fissure-in-Ano

Ulcerative skin tuberculosis (TB) is a rare form of extrapulmonary TB.. We present a case of a 65-year-old patient with perianal ulcer, which had been present for 1 year. Anamnesis revealed he had been persistently coughing for the same period of time. Histological examination of perianal skin showed necrotizing granulomatous lesions, acid-fast staining in sputum samples was ++++, TB antibody in the blood was positive, TB DNA test was positive, and chest scan that showed secondary pulmonary TB accompanied by possible pulmonary cavity formation in the 2 upper lungs.. Anti-TB therapy with isoniazid, rifampicin, ethambutol, and pyrazinamide for 6 months. The skin ulcer completely healed after 6 months.. TB should be suspected for nonhealing ulcers. Pertinent studies should be done early during the lesion; finally, TB treatment should be initiated immediately after diagnosis is made.

Topics: Aged; Antitubercular Agents; Ethambutol; Fissure in Ano; Humans; Isoniazid; Male; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Sputum; Tomography, X-Ray Computed; Treatment Outcome; Tuberculosis, Cutaneous; Tuberculosis, Pulmonary

Topics: Adult; Antibiotics, Antitubercular; Antitubercular Agents; Ethambutol; Fissure in Ano; Humans; Isoniazid; Male; Pyrazinamide; Rifampin; Tuberculosis, Gastrointestinal