rifampin and Erythema

Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Erythema; Humans; Interferon Type I; Lepromin; Leprostatic Agents; Leprosy, Lepromatous; Recombinant Proteins; Rifampin

Topics: Clofazimine; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Erythema; Humans; Leprostatic Agents; Leprosy, Lepromatous; Male; Rifampin; Treatment Outcome; Young Adult

A small percentage of patients with tuberculosis present with cutaneous findings, which may be difficult to diagnose. We present a patient diagnosed with a rare, non-scarring form of cutaneous tuberculosis (CTB), classically termed as lupus vulgaris erythematoides.

Topics: Adrenal Cortex Hormones; Aged, 80 and over; Anti-Bacterial Agents; Antitubercular Agents; Biopsy; Calcineurin Inhibitors; Dermis; Diagnostic Errors; Drug Therapy, Combination; Eczema; Erythema; Facial Dermatoses; Female; Histiocytosis, Langerhans-Cell; Humans; Immunosuppressive Agents; Isoniazid; Lupus Vulgaris; Mycobacterium tuberculosis; Necrosis; Nose Diseases; Pyrazinamide; Rifampin

A 43-year-old man visiting Texas from Hawaii sought care at our dermatology clinic for nonpruritic erythematous plaques on his chest, back, and extremities. The patient reported occasional numbness in his fingers and feet, but denied constitutional symptoms. The patient, who'd had these symptoms for a year, had been previously diagnosed with chronic urticaria and treated with oral antihistamines. He reported that the lesions were never particularly pruritic and he had not responded to previous treatments. An avid outdoorsman, our patient was born and raised in Texas and had been living in Hawaii. His past medical history was significant for severe hand eczema and when asked about medications he was taking, he listed cetirizine, doxepin, and hydroxyzine. On physical examination the patient had multiple pink to red, nonscaly to minimally scaly flat plaques on his forehead, chest, proximal upper extremities, lower back, and distal lower extremities. A 4-mm punch biopsy was taken from a lesion on his lower back and sent for histologic evaluation. The patient's erythrocyte sedimentation rate, rapid plasma reagin, and complete blood count were all within normal limits. What is your diagnosis? How would you treat this patient?

Topics: Adult; Animals; Armadillos; Biopsy; Clofazimine; Dapsone; Diagnosis, Differential; Drug Therapy, Combination; Erythema; Hand Dermatoses; Humans; Leprostatic Agents; Leprosy, Multibacillary; Male; Rifampin; Skin; Zoonoses

Topics: Adult; Antibiotics, Antitubercular; Anticonvulsants; Antitubercular Agents; Erythema; Ethambutol; Exanthema; Female; Humans; Phenobarbital; Phenytoin; Pruritus; Rifampin

At one time it was believed that granuloma annulare was associated with or even caused by tuberculosis. In the past 50 years, that idea has seemed to be of little more than historic importance. A case is reported of chronic, inadequately treated tuberculosis with erythema induratum in which clinical and histologic lesions compatible with granuloma annulare occurred. Specific antituberculosis therapy caused clearing of the skin lesions. The previous reported cases of granuloma annulare and tuberculosis are summarized. Other systemic diseases reportedly associated with granuloma annulare are noted to emphasize the many possible etiologic relationships. Granuloma annulare may be viewed not as a disease sui generis but as a phenotypic macrophage-granulomatous response to multiple etiologic disease patterns.

Topics: Antitubercular Agents; Back; Diagnosis, Differential; Erythema; Female; Granuloma Annulare; Humans; Leg Ulcer; Middle Aged; Phenotype; Radiography; Rifampin; Tuberculosis, Pulmonary

Topics: Child, Preschool; Erythema; Humans; Male; Rifampin; Syndrome

The use of rifampin and clofazimine ointments alone and in combination over the patches of tuberculoid patients had a beneficial effect. In combination (rifampin and clofazimine), erythema, inflammation, and edema are considerably reduced. For some of the cases with a recent appearance of a patch, the patch completely disappeared. It is suggested that topical therapy with rifampin and clofazimine ointments would be economical and beneficial in tuberculoid leprosy.

Topics: Clofazimine; Dermatitis; Drug Combinations; Edema; Erythema; Humans; Leprosy, Tuberculoid; Ointments; Rifampin

Topics: Cerebrospinal Fluid Shunts; Diphenhydramine; Drug Eruptions; Erythema; Humans; Infant; Infusions, Intravenous; Male; Premedication; Rifampin

Topics: Bone Marrow; Bone Marrow Examination; Cholestasis; Erythema; Ethambutol; Humans; Isoniazid; Leukopenia; Male; Middle Aged; Neutropenia; Peritonitis, Tuberculous; Rifampin; Streptomycin; Thrombocytopenia; Tuberculosis; Tuberculosis, Hepatic; Tuberculosis, Osteoarticular; Tuberculosis, Splenic; Vitamin B Complex

Topics: Cryoglobulins; Erythema; Humans; Hypersensitivity; Purpura; Rifampin; Skin; Skin Diseases; Syndrome; Vascular Diseases