rifampin and Duodenal-Ulcer

Human brucellosis is a multisystemic infectious disease with a broad spectrum of clinical manifestations. Severe complications involving musculoskeletal, nervous, genitourinary, and cardiovascular systems may be encountered during the course of the disease; however, cutaneous complications have been reported rarely. We report a patient with brucellosis in whom the main presenting clinical feature was a maculopapular rash and fever. He was initially diagnosed as brucellosis based on the standard tube agglutination test and blood culture positivity. Histopathologic examination of these maculopapular lesions showed perivascular and periadnexal inflammation with loose granuloma formation including giant cells. We emphasize that brucellosis is an infectious disease that should always be kept in mind in the differential diagnosis of a patient with rash and fever, especially in endemic areas.

Topics: Agglutination Tests; Anti-Bacterial Agents; Antihypertensive Agents; Brucellosis; Diagnosis, Differential; Doxycycline; Drug Therapy, Combination; Duodenal Ulcer; Exanthema; Humans; Hypertension; Lymphoma, T-Cell, Cutaneous; Male; Middle Aged; Rifampin; Skin Neoplasms

Antibiotic resistance in Helicobacter pylori has been a growing problem with current treatment regimens. However, second-line therapy for cases with eradication failure remains to be established. The aim of this study was to evaluate (in vitro) the potential use of rifampicin for H. pylori eradication. The susceptibility of 52 H. pylori strains isolated from children and adults to amoxicillin, clarithromycin, metronidazole and rifampicin was determined. Forty H. pylori isolates susceptible to these antibiotics were investigated for in vitro inducement of resistance. All isolates were susceptible to rifampicin. None of the H. pylori isolates tested acquired rifampicin resistance during prolonged exposure in in vitro inducement experiments. It is suggested that rifampicin has stable activity against H. pylori.

Topics: Adolescent; Adult; Amoxicillin; Biopsy; Child; Child, Preschool; Clarithromycin; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Duodenal Ulcer; Gastritis; Gastroscopy; Helicobacter Infections; Helicobacter pylori; Humans; Metronidazole; Microbial Sensitivity Tests; Rifampin