rifampin and Dermatitis--Contact

The literature has been reviewed for contact dermatitis occurring to antituberculosis agents. Of the 12 known drugs, 6 (isoniazid, rifampicin, ethambutol, para-aminosalicylic acid, streptomycin and kanamycin) have been documented by patch test to cause this type of dermatitis in certain individuals. Cross sensitization has been observed to contribute significantly to the allergic reactions noted from isoniazid, streptomycin, and kanamycin. Hyposensitization has also been discussed in this review.

Topics: Aminosalicylic Acid; Antitubercular Agents; Cross Reactions; Dermatitis, Contact; Desensitization, Immunologic; Ethambutol; Humans; Isoniazid; Kanamycin; Rifampin; Skin Tests; Streptomycin

Treatment of mice with rifampin (Ri, 100-200 mg/kg) affected the course of contact sensitivity (CS) reactions to oxazolone. The effects which were seen as either partial inhibition or enhancement of the response, under one set of conditions, could be abrogated or even reversed if conditions of either induction, elicitation and time of measuring reactions were altered. In addition, amount of Ri used for treatment and time of treatment in relation to the induction of CS reactions also influenced the effects observed.

Topics: Animals; Dermatitis, Contact; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred BALB C; Oxazolone; Rifampin; Time Factors

Topics: Animals; Dermatitis, Contact; Guinea Pigs; Immunosuppressive Agents; Nitrobenzenes; Organ Size; Rifampin; Spleen; Thymus Gland

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dermatitis, Contact; Eczema; Female; Furunculosis; Humans; Infant; Lupus Vulgaris; Male; Middle Aged; Pyoderma; Rifampin; Skin Diseases; Syphilis, Cutaneous; Tuberculosis, Cutaneous